A functional in vivo shRNA screen for regulators of breast cancer metastasis.

如果在肿瘤扩散到其他器官后被发现，乳腺癌通常是无法治愈的。将肿瘤细胞转移到其他位置的基因还没有得到明确的解决。该项目旨在通过使用全基因组功能屏幕来识别控制乳腺癌扩散的基因，从而加快发现过程。如果成功，该项目可能很快就能识别出可能成为治疗晚期乳腺癌新疗法的良好靶点的基因。

Breast cancer is generally incurable if detected after the tumour has spread to other organs. The genes driving the tumour cells to other sites have not been clearly resolved. This project aims to accelerate the discovery process by using a genome wide functional screen to identify genes that control the spread of breast cancer. If successful, this project could lead very quickly to identification of genes that might be good targets for new therapy against advanced breast cancer.