课题基金 / 基金详情

NEURAL CONTROL OF MAGNOCELLULAR NEUROENDOCRINE CELLS

NEURAL CONTROL OF MAGNOCELLULAR NEUROENDOCRINE CELLS
巨细胞神经内分泌细胞的神经控制
批准号:
6187027
负责人:
GLENN I HATTON
金额:
$25.56万
依托单位国家:
美国
项目类别:
财政年份:
1981
资助国家:
美国
项目状态:
已结题
起止时间:
1981-01-01 至 2002-05-31

项目摘要

项目成果

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中文摘要
翻译
所建议的工作的长期目标是了解控制
英文摘要
Long-term goals of the proposed work are to understand controlling mechanisms involved in the normal functioning of the adult mammalian hypothalamus. Specifically, this work centers on the magnocellular neuroendocrine cells (MNCS) of the hpothalamo-neurohypophysial system (HNS), consisting chiefly of the supraoptic (SON) and paraventricular (PVN) nuclei and their axonal projections. MNCs synthesize either oxytocin or vasopressin and, in response to physiological stimuli, release these peptides from axon terminals in the pituitary neural lobe or within the CNS. Well known to play important roles in water regulation, control of blood pressure, reproductive physiology and care of the young, this model system has yielded many insights into CNS functioning. So well studied are the peripheral effects of HNS outputs that even results from in vitro experiments with the SON and PVN can often be related directly to the functioning of the intact animal. In order to further the central mission of this work, this proposal focuses on two main aspects of HNS functioning: interactions among the MNCs themselves, particularly interneuronal coupling, and extrinsic and intrinsic factors that modulate MNC excitability. The proposed studies will use electrophysiological methods, intracellular an patch-clamp recording techniques in brain slices, accompanied by immunocytochemical and biochemical approaches, all aimed at uncovering fundamental mechanisms of CNS functioning. Specific aims are: Aim 1. To continue our investigations of interneuronal coupling in the SON. Experiments will further define the physiological conditions that enhance or diminish coupling, define the relationships between receptor activation and coupling, and determine cellular mechanisms that modulate MNC coupling. Aim 2. To continue investigation determining the mechanisms by which physiological changes alter MNC excitability. Specific studies will investigate the contributions of neuronal histamine, oxytocin, and intrinsic ionic mechanisms to MNC excitability and, thus, to mechanisms ultimately governing peptide release. Factors to be investigated include: depolarizing after potentials, plateau potentials, receptor-mediated conductances, and termination of bursts of phasic firing, as well as physiological state of the animal.
期刊论文(49)
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会议论文
Some well-kept hypothalamic secrets disclosed.
一些保守的下丘脑秘密被披露。
DOI: --
发表时间: 1983
期刊: Federation proceedings
影响因子: --
作者: [Hatton,GI]
通讯作者: Hatton,GI
Inositol 1,4,5-trisphosphate-sensitive Ca2+ stores in rat supraoptic neurons: involvement in histamine-induced enhancement of depolarizing afterpotentials.
大鼠视上神经元中肌醇 1,4,5-三磷酸敏感的 Ca2 储存:参与组胺诱导的去极化后电位增强。
DOI: 10.1016/s0306-4522(99)00168-2
发表时间: 1999
期刊: Neuroscience
影响因子: 3.3
作者: [Li,Z, Miyata,S, Hatton,GI]
通讯作者: Hatton,GI
Connexin 32 mRNA levels in the rat supraoptic nucleus: up-regulation prior to parturition and during lactation.
大鼠视上核中的连接蛋白 32 mRNA 水平:分娩前和哺乳期间上调。
DOI: 10.1159/000126933
发表时间: 1996
期刊: Neuroendocrinology
影响因子: 4.1
作者: [Micevych,PE, Popper,P, Hatton,GI]
通讯作者: Hatton,GI
Incidence of neuronal coupling in supraoptic nuclei of virgin and lactating rats: estimation by neurobiotin and lucifer yellow.
处女和哺乳大鼠视上核神经元耦合的发生率:通过神经生物素和荧光黄进行估计。
DOI: 10.1016/0006-8993(94)90207-0
发表时间: 1994
期刊: Brain research
影响因子: 2.9
作者: [Hatton,GI, Yang,QZ]
通讯作者: Yang,QZ
32
    INTERDISCIPLINARY NEUROSCIENCE TRAINING PROGRAM
    • 批准号:
      3544042
    • 项目类别:
    • 资助金额:
      $8.72万
    • 财政年份:
      1987
    • 负责人:
      GLENN I HATTON
    • 依托单位:
    INTERDISCIPLINARY NEUROSCIENCE TRAINING PROGRAM
    • 批准号:
      3544038
    • 项目类别:
    • 资助金额:
      $12.75万
    • 财政年份:
      1987
    • 负责人:
      GLENN I HATTON
    • 依托单位:
    INTERDISCIPLINARY NEUROSCIENCE TRAINING PROGRAM
    • 批准号:
      3544041
    • 项目类别:
    • 资助金额:
      $14.11万
    • 财政年份:
      1987
    • 负责人:
      GLENN I HATTON
    • 依托单位:
    INTERDISCIPLINARY NEUROSCIENCE TRAINING PROGRAM
    • 批准号:
      3544040
    • 项目类别:
    • 资助金额:
      $12.8万
    • 财政年份:
      1987
    • 负责人:
      GLENN I HATTON
    • 依托单位:
    海外基金