MODERATE ALCOHOL USE & HEALTH: PREFERENCES & OUTCOMES

该提案寻求一个以患者为导向的导师研究职业发展奖。候选人建议利用这一奖项来促进研究适度饮酒对特定健康措施的影响的研究事业。职业发展计划的目标有四个方面：(1)在从个人那里获得个人偏好和价值观方面的方法专长，特别是与饮酒有关的个人偏好和价值观；(2)在量化行为因素对患者群体中指定的健康结果的影响方面获得经验；(3)发展决策分析方面的专长，通过结合个人偏好和结果数据为患者决策提供信息；以及(4)利用这些研究的结果建立研究独立性。在一项有组织的计划中，申请者将接受哈佛公共卫生学院的正式培训，并从Murray Mittleman医学博士那里毕业指导，Murray Mittleman是波士顿贝丝以色列女执事医疗中心心脏病行为决定因素的活跃研究员。这些职业发展目标与研究计划密切相关，研究计划将在他们被连续掌握后使用它们。该研究计划的总体目标是了解个人如何看待适度饮酒的相互竞争的风险和好处，以及这些相互竞争的因素实际上如何影响健康。研究计划将包括三项相关研究：(1)开发一种调查工具，由申请者在不同的门诊环境中向患者实施，以确定他们对适度饮酒的偏好及其影响；(2)在心肌梗死发病决定因素研究中分析饮酒对急性心肌梗死后存活率的影响；以及(3)利用冠心病政策模型评估人群中适度饮酒对总死亡率的影响，利用调查结果改进政策模型结果的适用性。

This proposal seeks a Mentored Patient-Oriented Research Career Development Award. The candidate proposes to use this award to foster a research career in the study of the effect of moderate alcohol consumption on specific health measures. The aims of the career development plan are fourfold: (1) to develop methodologic expertise in eliciting personal preferences and values from individuals, particularly related to alcohol use; (2) to gain experience in quantifying the effect of behavioral factors on designated health outcomes amongst groups of patients; (3) to develop expertise in the use of decision analysis to inform patient decision-making by combining personal preferences and outcomes data; and (4) to use the results of these studies to establish research independence. In a structured program, the applicant will receive formal training at the Harvard School of Public Health and graduated supervision from Murray Mittleman, MD, DrPH, an active investigator in the behavioral determinants of heart disease at Beth Israel Deaconess Medical Center in Boston. These career development goals closely parallel the research plan, which will employ them as they are mastered in succession. The overall aim of the research program is to understand how individuals view the competing risks and benefits of moderate alcohol consumption and how those competing factors actually influence health. The research program will comprise three related studies: (1) development of a survey instrument to be administered by the applicant to patients in different outpatient settings to determine their preferences about moderate alcohol consumption and its effects; (2) analysis of the effect of alcohol use on survival following acute myocardial infarction in the Determinants of Myocardial Infarction Onset Study; and (3) assessment of the populationwide effect of moderate alcohol use on total mortality with the Coronary Heart Disease Policy Model, using the survey results to refine the applicability of the Policy Model findings.