DEVELOPMENT OF A REGIONAL TUMOR IMAGING RESOURCE

在过去的几年里，密歇根大学对小动物肿瘤模型的非侵入性成像的兴趣急剧增加。为了帮助研究人员满足成像要求，开发了磁共振成像(MRI)和数字图像处理实验室(DPL)，作为密歇根大学综合癌症中心核心设施的一部分。核磁共振和数字地球物理实验室目前可协助数量有限的调查人员获取成像数据和进行后处理。人们对这项技术的兴趣已经超过了设备的能力和实验室人员的数量。这项建议的目标是：1)更新和扩展我们的2T和7T横孔动物磁共振成像和光谱分析系统(磁共振/S)的功能，包括增加我们的2T和7T横孔动物磁共振成像和光谱分析系统(MRI/S)的微成像功能，包括增加高分辨率小鼠肿瘤成像的微成像功能。2)获得一台既能扫描小鼠又能扫描大鼠的微型X射线计算机断层扫描(CT)设备。3)提供获得肿瘤定量放射自显影数据的能力，以便与磁共振/S和CT数据进行对比。4)增加可用于协助调查人员掌握这些技术的人员数量。5)开发和实施新的成像和后处理能力，以增强成像数据的定量分析。6)通过与相关人员协商和小额种子赠款，为妇女、少数群体和青年调查人员提供使用这些设施的机会。7)发起向所有科学家开放的季度研讨会系列，以鼓励互动和思想交流。这些目标是为了让密歇根大学的小动物特别重要，因为我们目前的用户群包括密歇根大学和明尼苏达州密歇根州威斯康星州其他学术机构的许多教职员工，以及一家当地公司的研究员，该公司由NIH SBIR资助进行癌症研究。这项提案的总体目标将是提供一个共享资源，以改进癌症研究人员可以用来追求他们个人研究兴趣的工具。显着提高我们的成像便利的能力和吞吐量将使更多的研究人员获得这些技术，并将提供更多样化和更动态的技术和思想交流。这种类型的互动肯定会促进癌症研究中的跨学科合作。

There has been a dramatic increase in interest in noninvasive imaging of small animal tumor models at the University of Michigan over the past several years. In order to assist investigators with imaging requirements, a Magnetic Resonance Imaging (MRI) and Digital Image Processing Laboratory (DIPL) were developed as part of the University of Michigan Comprehensive Cancer Center Core Facilities. The MRI and DIPL core labs are currently available to assist a limited number of investigators with acquisition of imaging data and post processing. The interest in this technology has outgrown both the capabilities of the equipment as well as the number of laboratory personnel. The objectives of this proposal are to: 1) Update and expand the capabilities of our 2T and 7T horizontal bore animal MR imaging and spectroscopy systems (MRI/S) including adding microimaging capabilities of our 2T and 7T horizontal bore animal MR imaging and spectroscopy systems (MRI/S) including adding microimaging capabilities for high-resolution mouse tumor imaging. 2) Acquire a miniature x-ray computed tomography (CT) device capable of scanning both mice and rats. 3) Provide the capability to obtain quantitative autoradiographic data of tumors for correlation and comparison with MRI/S and CT data. 4) Increase the number of personnel available to assist investigators with these technologies. 5) Develop and implement new imaging and post processing capabilities to enhance the quantitative analysis of imaging data. 6) Provide opportunities for women, minority and young investigators to use these facilities through consultation with relevant personnel and small seed grants. 7) Initiate a quarterly seminar series open to all scientists to encourage interactions and exchange of ideas. These objectives were defined to bring the University of Michigan small animal especially important since our current user base encompasses many faculty at the University of Michigan and other academic institutions in Michigan, Wisconsin, Minnesota, as well as an investigator at a local company with NIH SBIR funding for cancer research. The overall goal of this proposal will be to provide a shared resource to improve the tool that cancer researchers can utilize to pursue their individual research interests. Significantly improving the capabilities and throughput of our imaging facilitate will give more investigators access to these technologies and will provide a more diverse and dynamic exchange of techniques and ideas. This type of interaction will surely foster interdisciplinary collaborations in cancer research.