CORE--BIOSTATISTICS

核心--生物统计学

• 批准号: 6315631
• 负责人: RODERICK J. LITTLE
• 金额: $ 22.35万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-01 至 2001-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6315631
• 关键词: Alzheimer's disease; biomedical facility; computer data analysis; dementia; experimental designs; human data; longitudinal human study; patient /disease registry; postmortem; psychometrics; statistics /biometry; training

The Biostatistics Core will promote the goals of the Michigan Alzheimer's Research Center (MADRC) and serve the needs of individual projects by providing centralized management of clinical and research data and statistical expertise in experimental design and data analysis. The Core will continue to maintain and develop a relational multi user database for the MADRC consisting of (a) a registry of normal subjects and patients evaluated by the Clinical Core, together with information concerning their appropriateness for clinical studies; and (b) extensive clinical and research data on the subset of patients in (a) who are participating in research studies or who are being followed longitudinally over the course of their illness. The Biostatistics Core will facilitate the ongoing collaborative research in the MADRC by integrating the data from research projects, cores and satellites into this single database. The accuracy and completeness of the data will be assured by the use of established procedures for data entry, validation and verification. Interactive access to the database will be provided to personnel in other MADRC cores and projects, and to the Alzheimer's Disease Data Coordinating Center, under guidelines established to maintain patient confidentiality and the integrity of individual investigator's data. Core personnel will provide training to investigators in the use of the database to access individual records and generate patient lists. The Biostatistics Core will collaborate with MADRC investigators in the design and analysis of their research project son dementia-related topics prior to their submission to the MADRC and funding agencies. Core personnel will assist project investigators in the completion of statistical analyses of their data by providing advice and training to MADRC-affiliated investigators in routine analysis, and by carrying out more complex statistical analyses for project investigators.

生物统计学核心将促进密歇根州阿尔茨海默氏症研究中心（MADRC）的目标，并通过提供对临床和研究数据的集中管理以及实验设计和数据分析方面的统计专业知识来满足各个项目的需求。核心将继续维护和开发一个由（a）由临床核心评估的正常受试者和患者的注册表组成的MADRC的关系多用户数据库，以及有关其临床研究适当性的信息； （b）（a）中参与研究或在疾病过程中纵向跟踪的患者子集的大量临床和研究数据。生物统计学核心将通过将研究项目，核心和卫星的数据集成到该单个数据库中，从而促进MADRC正在进行的合作研究。通过使用已建立的程序输入，验证和验证，可以确保数据的准确性和完整性。根据为维持患者机密性和个人调查员数据的完整性而建立的指南，将向其他MADRC核心和项目的人员以及阿尔茨海默氏病数据协调中心提供交互式访问数据库。核心人员将向调查人员提供使用数据库访问单个记录并生成患者清单的培训。生物统计学核心将与MADRC调查人员合作，在其研究项目SON与Dementia相关的主题的设计和分析中，然后才提交MADRC和资助机构。核心人员将通过向MADRC附属研究人员提供建议和培训来协助项目调查人员完成数据的统计分析，并通过对项目调查人员进行更复杂的统计分析。