CORE--BIOSTATISTICS

核心--生物统计学

• 批准号: 6203847
• 负责人: RODERICK J. LITTLE
• 金额: $ 22.35万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-29 至 2004-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6203847
• 关键词: Alzheimer's disease; biomedical facility; computer data analysis; dementia; experimental designs; human data; longitudinal human study; patient /disease registry; postmortem; psychometrics; statistics /biometry; training

The Biostatistics Core will promote the goals of the Michigan Alzheimer's Research Center (MADRC) and serve the needs of individual projects by providing centralized management of clinical and research data and statistical expertise in experimental design and data analysis. The Core will continue to maintain and develop a relational multi user database for the MADRC consisting of (a) a registry of normal subjects and patients evaluated by the Clinical Core, together with information concerning their appropriateness for clinical studies; and (b) extensive clinical and research data on the subset of patients in (a) who are participating in research studies or who are being followed longitudinally over the course of their illness. The Biostatistics Core will facilitate the ongoing collaborative research in the MADRC by integrating the data from research projects, cores and satellites into this single database. The accuracy and completeness of the data will be assured by the use of established procedures for data entry, validation and verification. Interactive access to the database will be provided to personnel in other MADRC cores and projects, and to the Alzheimer's Disease Data Coordinating Center, under guidelines established to maintain patient confidentiality and the integrity of individual investigator's data. Core personnel will provide training to investigators in the use of the database to access individual records and generate patient lists. The Biostatistics Core will collaborate with MADRC investigators in the design and analysis of their research project son dementia-related topics prior to their submission to the MADRC and funding agencies. Core personnel will assist project investigators in the completion of statistical analyses of their data by providing advice and training to MADRC-affiliated investigators in routine analysis, and by carrying out more complex statistical analyses for project investigators.

生物统计学核心将促进密歇根阿尔茨海默氏症研究中心（MADRC）的目标，并通过提供临床和研究数据的集中管理以及实验设计和数据分析的统计专业知识来满足各个项目的需求。核心将继续为MADRC维护和开发一个多用户关系数据库，包括：（a）由临床核心评价的正常受试者和患者的登记，以及有关其临床研究适用性的信息;和（B）关于（a）中患者子集的广泛临床和研究数据他们正在参与研究性研究，或者在他们的疾病过程中被纵向跟踪。生物统计核心将通过将研究项目、核心和卫星的数据整合到这个单一的数据库中，促进MADRC正在进行的合作研究。将通过使用既定的数据输入、验证和核实程序来确保数据的准确性和完整性。根据为维护患者机密性和个体研究者数据完整性而制定的指导方针，将向其他MADRC核心和项目的人员以及阿尔茨海默病数据协调中心提供对数据库的交互式访问。核心人员将为研究者提供使用数据库访问个人记录和生成患者列表的培训。生物统计学核心将与MADRC研究人员合作，在提交给MADRC和资助机构之前设计和分析他们的研究项目。核心人员将协助项目调查人员完成其数据的统计分析，向MADRC附属调查人员提供常规分析方面的建议和培训，并为项目调查人员进行更复杂的统计分析。