CORE--BIOSTATISTICS

核心--生物统计学

• 批准号: 6203847
• 负责人: RODERICK J. LITTLE
• 金额: $ 22.35万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-29 至 2004-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6203847
• 关键词: Alzheimer's disease; biomedical facility; computer data analysis; dementia; experimental designs; human data; longitudinal human study; patient /disease registry; postmortem; psychometrics; statistics /biometry; training

The Biostatistics Core will promote the goals of the Michigan Alzheimer's Research Center (MADRC) and serve the needs of individual projects by providing centralized management of clinical and research data and statistical expertise in experimental design and data analysis. The Core will continue to maintain and develop a relational multi user database for the MADRC consisting of (a) a registry of normal subjects and patients evaluated by the Clinical Core, together with information concerning their appropriateness for clinical studies; and (b) extensive clinical and research data on the subset of patients in (a) who are participating in research studies or who are being followed longitudinally over the course of their illness. The Biostatistics Core will facilitate the ongoing collaborative research in the MADRC by integrating the data from research projects, cores and satellites into this single database. The accuracy and completeness of the data will be assured by the use of established procedures for data entry, validation and verification. Interactive access to the database will be provided to personnel in other MADRC cores and projects, and to the Alzheimer's Disease Data Coordinating Center, under guidelines established to maintain patient confidentiality and the integrity of individual investigator's data. Core personnel will provide training to investigators in the use of the database to access individual records and generate patient lists. The Biostatistics Core will collaborate with MADRC investigators in the design and analysis of their research project son dementia-related topics prior to their submission to the MADRC and funding agencies. Core personnel will assist project investigators in the completion of statistical analyses of their data by providing advice and training to MADRC-affiliated investigators in routine analysis, and by carrying out more complex statistical analyses for project investigators.

生物统计学核心将促进密歇根阿尔茨海默病研究中心 (MADRC) 的目标，并通过提供临床和研究数据的集中管理以及实验设计和数据分析方面的统计专业知识来满足各个项目的需求。核心将继续为 MADRC 维护和开发一个关系型多用户数据库，其中包括 (a) 由临床核心评估的正常受试者和患者的登记册，以及有关其是否适合临床研究的信息； (b) 关于 (a) 中正在参与研究或在病程中接受纵向随访的患者子集的广泛临床和研究数据。生物统计核心将通过将研究项目、核心和卫星的数据整合到这个单一数据库中，促进 MADRC 正在进行的合作研究。通过使用既定的数据输入、验证和验证程序，将确保数据的准确性和完整性。根据为维护患者机密性和个人研究人员数据完整性而制定的指导方针，其他 MADRC 核心和项目以及阿尔茨海默病数据协调中心的人员将可以交互式访问数据库。核心人员将为研究人员提供使用数据库访问个人记录并生成患者名单的培训。生物统计核心将与 MADRC 研究人员合作，设计和分析其与痴呆症相关主题的研究项目，然后再将其提交给 MADRC 和资助机构。核心人员将通过向 MADRC 附属调查人员提供日常分析方面的建议和培训，以及为项目调查人员进行更复杂的统计分析，协助项目调查人员完成数据统计分析。