CORE--DATA MANAGMENENT AND STATISTICS CORE

核心--数据管理与统计核心

• 批准号: 6933384
• 负责人: RODERICK J. LITTLE
• 金额: $ 14.29万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6933384
• 关键词: Alzheimer' s disease; biomedical facility; computer data analysis; data collection methodology /evaluation; data management; dementia; experimental designs; human data; longitudinal human study; patient /disease registry; psychometrics; statistics /biometry

The Data Management and Statistics Core (henceforth abbreviated to Data Core) supports the MADRC in two areas: (1) data management; and (2) experimental design and statistical analysis. Data management specific aims are to continue to collect MADRC data from cores, the Minority Satellite and research studies and integrate this information in an existing relational multi-user research database. This database consists of a registry of patients and normal control subjects who have signed a form consenting the release of their medical records for potential participation in research studies, and have been evaluated by the Clinical Core, including information on their appropriateness for clinical studies; and research data on the subset of patients and normal control subjects who are participating in research studies, or are being followed longitudinally. The Data Core will work with projects and other cores to assure the accuracy and completeness of the data in the MADRC database using established procedures for data entry, validation and verification, modified where necessary to conform with new HTPAA guidelines for patient confidentiality. The Core will develop and extend the scope of the database to accommodate new requirements for data collection and real-time data submission from the National Alzheimer's Coordinating Center (NACC), under conditions that maintain patient confidentiality and the integrity of individual investigators' data Experimental Design and Statistical Analysis Aims of the Core are to provide leadership and assistance for MADRC-affiliated projects on all issues relating to statistical design and analysis; to provide statistical consultation for investigators in the design and analysis of research studies on dementia-related topics prior to their submission to the MADRC and funding agencies; and to provide review of statistical aspects of pilot projects and other research projects requesting use of MADRC resources.

数据管理和统计核心（Data Management and Statistics Core）在两个方面支持MADRC：（1）数据管理;（2）实验设计和统计分析。 数据管理的具体目标是继续收集来自核心、少数民族卫星和研究报告的MADRC数据，并将这些信息纳入现有的关系型多用户研究数据库。该数据库包括一个患者和正常对照受试者登记处，这些受试者已签署一份同意发布其医疗记录的表格，以便可能参与研究，并已由临床中心进行评价，包括关于其是否适合临床研究的信息;以及关于参与研究性研究或正在接受纵向随访的患者和正常对照受试者子集的研究数据。数据核心将与项目和其他核心合作，以确保MADRC数据库中数据的准确性和完整性，使用既定的数据输入，验证和验证程序，必要时进行修改，以符合新的HTPAA患者保密指南。核心将开发和扩展数据库的范围，以适应国家阿尔茨海默氏症协调中心（NACC）对数据收集和实时数据提交的新要求，在维护患者机密性和个体研究者数据完整性的条件下，核心的实验设计和统计分析目的是为MADRC提供领导和帮助-就与统计设计和分析有关的所有问题开展附属项目;在痴呆症相关主题的研究报告提交给MADRC和资助机构之前，为研究人员提供设计和分析方面的统计咨询;并对要求使用MADRC资源的试验项目和其他研究项目的统计方面进行审查。