CORE--ANIMAL SURGERY

动物外科核心旨在执行所有手术 测试整个集团中每一个产品所需的程序 假设和四个项目的具体目标。 它 由项目主管和动物外科技术员组成。 核心的目标和职能如下：1）执行所有 整个项目所需的动物操作程序; 2） 监测手术动物的健康状况; 3）安排 实验和手术; 4）协助组织切除， 分发到项目实验室;以及5）准备肌肉， 用于收缩性能的体外测试。 操作 要执行的是标准，神经植入，和神经完整的肌肉 移植、神经横断和永久性去神经，以及 注射局部麻醉剂以产生肌肉 纤维变性 实验动物的饲养， 沿着处理动物病理学，将由 密歇根大学实验室动物医学单位。

The Animal Surgery core is designed to perform all the operative procedures required for the testing of each of the overall Group Hypotheses and for the Specific Aims of each of the four Projects. It is staffed by the Project director and the animal surgery technician. Objectives and functions of the core are as follows: 1) to perform all of the animal operative procedures needed for the entire Project; 2) to monitor the health status of the operated animals; 3) to schedule experiments and operations; 4) to assist in tissue removal and distribution to the Project laboratories; and 5) to prepare muscles that are used for the in vitro testing of contractile properties. Operations to be performed are standard, nerve-implant, and nerve-intact muscle grafts, nerve transections and permanent denervations, as well as injections of local anesthetics for the purpose of producing muscle fiber degeneration. The maintenance of the experimental animals, along with dealing with animal pathology, will be supervised by the unit for laboratory Animal Medicine at the University of Michigan.