CORE--ANIMAL SURGERY

核心--动物外科

• 批准号: 6344581
• 负责人: BRUCE M CARLSON
• 金额: $ 15.44万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-15 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6344581
• 关键词: age difference; animal care; biomedical facility; laboratory rat; muscle transplantation; nervous system transplantation; neurosurgery; tissue /cell preparation

The Animal Surgery core is designed to perform all the operative procedures required for the testing of each of the overall Group Hypotheses and for the Specific Aims of each of the four Projects. It is staffed by the Project director and the animal surgery technician. Objectives and functions of the core are as follows: 1) to perform all of the animal operative procedures needed for the entire Project; 2) to monitor the health status of the operated animals; 3) to schedule experiments and operations; 4) to assist in tissue removal and distribution to the Project laboratories; and 5) to prepare muscles that are used for the in vitro testing of contractile properties. Operations to be performed are standard, nerve-implant, and nerve-intact muscle grafts, nerve transections and permanent denervations, as well as injections of local anesthetics for the purpose of producing muscle fiber degeneration. The maintenance of the experimental animals, along with dealing with animal pathology, will be supervised by the unit for laboratory Animal Medicine at the University of Michigan.

动物手术核心旨在执行所有手术 整个组中每个部分的测试所需的程序 四个项目各自的假设和具体目标。 它 其工作人员包括项目总监和动物外科技术员。 核心的目标和功能如下： 1）执行所有 整个项目所需的动物操作程序； 2）到 监测手术动物的健康状况； 3）安排 实验和操作； 4) 协助组织去除和 分发给项目实验室； 5）准备肌肉 用于收缩特性的体外测试。 运营 进行的是标准的、神经植入的和神经完整的肌肉 移植、神经横断和永久性去神经术，以及 注射局部麻醉剂以产生肌肉 纤维变性。 实验动物的维护、 在处理动物病理学的同时，将受到 密歇根大学实验动物医学单位。