课题基金 / 基金详情

QTL ANALYSIS OF AGE RELATED PHENOTYPES

QTL ANALYSIS OF AGE RELATED PHENOTYPES
年龄相关表型的QTL分析
批准号:
2741437
负责人:
GERALD E MCCLEARN
金额:
$123.69万
依托单位国家:
美国
项目类别:
财政年份:
1999
资助国家:
美国
项目状态:
已结题
起止时间:
1999-02-01 至 2004-01-31

项目摘要

项目成果

GERALD E MCCLEARN的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
The broad objective of this program project proposal is to maintain two different groups of genetically defined mice under highly controlled laboratory conditions and assess cross-sectional samples of these mice on a variety of age-related behavioral, immunological, physiological, neurobiological, and pathological processes at three ages, representing young adulthood, midlife and old age. Longevity will be determined in a separate group. These animals-recombinant inbred (RI) strains derived from the C57BL/6 and DBA/2 inbred strains and an F2 generation derived from these same progenitor strains-- are complementary elements in a two-phase program of identify chromosomal locations of genes ("quantitative trait loci" or QTLs) that influence complex age-related traits. The localization of such QTLs will open up valuable research approaches both to the reductionist explorations of the mechanisms of aging processes, and also the integrative science relating interactions among genes and between genes and environmental factors in influencing the phenomena of aging.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Selective Breeding for Insulin Growth Factor 1 in Mice
Selective Breeding for Insulin Growth Factor 1 in Mice
CORE--ANIMAL MODEL
QUANTITATIVE TRAIT LOCI AND LONGEVITY
海外基金