QTL ANALYSIS OF AGE RELATED PHENOTYPES

年龄相关表型的QTL分析

• 批准号: 2741437
• 负责人: GERALD E MCCLEARN
• 金额: $ 123.69万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-02-01 至 2004-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2741437
• 关键词: aging; genetic markers; linkage mapping; phenotype; quantitative trait loci

The broad objective of this program project proposal is to maintain two different groups of genetically defined mice under highly controlled laboratory conditions and assess cross-sectional samples of these mice on a variety of age-related behavioral, immunological, physiological, neurobiological, and pathological processes at three ages, representing young adulthood, midlife and old age. Longevity will be determined in a separate group. These animals-recombinant inbred (RI) strains derived from the C57BL/6 and DBA/2 inbred strains and an F2 generation derived from these same progenitor strains-- are complementary elements in a two-phase program of identify chromosomal locations of genes ("quantitative trait loci" or QTLs) that influence complex age-related traits. The localization of such QTLs will open up valuable research approaches both to the reductionist explorations of the mechanisms of aging processes, and also the integrative science relating interactions among genes and between genes and environmental factors in influencing the phenomena of aging.

该方案项目提案总体目标是维持两个 在高度控制下的不同组基因定义的小鼠 实验室条件和评估这些小鼠的横断面样本 一系列与年龄相关的行为，免疫，生理， 三个年龄段的神经生物学和病理过程，代表 青壮年、中年和老年。长寿将在一个 单独的小组。这些动物-重组近交系(RI)菌株来自 从C57BL/6和DBA/2近交系和F2代衍生 从这些相同的祖先菌株-是互补的元素在一个 确定基因染色体位置的两阶段规划 (“数量性状基因座”或QTL)，影响复杂的年龄相关 特征。这些QTL的本地化将开启有价值的研究 这两种方法都是简化论的机制探索 衰老过程，以及与相互作用相关的综合科学 基因之间以及基因与环境因素之间的影响 衰老现象。