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QTL ANALYSIS OF AGE RELATED PHENOTYPES

QTL ANALYSIS OF AGE RELATED PHENOTYPES
年龄相关表型的QTL分析
批准号：
6627926
负责人：
GERALD E MCCLEARN
金额：
$147.29万
依托单位：
PENNSYLVANIA STATE UNIVERSITY, THE
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-02-01 至 2006-01-31
来源：
https://reporter.nih.gov/project-details/6627926
关键词：
aging genetic markers linkage mapping phenotype quantitative trait loci

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中文摘要
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英文摘要
The broad objective of this program project proposal is to maintain two different groups of genetically defined mice under highly controlled laboratory conditions and assess cross-sectional samples of these mice on a variety of age-related behavioral, immunological, physiological, neurobiological, and pathological processes at three ages, representing young adulthood, midlife and old age. Longevity will be determined in a separate group. These animals-recombinant inbred (RI) strains derived from the C57BL/6 and DBA/2 inbred strains and an F2 generation derived from these same progenitor strains-- are complementary elements in a two-phase program of identify chromosomal locations of genes ("quantitative trait loci" or QTLs) that influence complex age-related traits. The localization of such QTLs will open up valuable research approaches both to the reductionist explorations of the mechanisms of aging processes, and also the integrative science relating interactions among genes and between genes and environmental factors in influencing the phenomena of aging.
期刊论文(33)
专著(0)
科研奖励(0)
会议论文
Duloxetine pharmacology: profile of a dual monoamine modulator.
度洛西汀药理学：双重单胺调节剂的概况。
DOI： 10.1111/j.1527-3458.2002.tb00234.x
发表时间： 2002
期刊： CNS drug reviews
影响因子： --
作者： [Karpa,KellyD, Cavanaugh,JaneE, Lakoski,JoanM]
通讯作者： Lakoski,JoanM
Genomic analysis of variation in hindlimb musculature of mice from the C57BL/6J and DBA/2J lineage.
C57BL/6J 和 DBA/2J 谱系小鼠后肢肌肉组织变异的基因组分析。
DOI： 10.1093/jhered/esq023
发表时间： 2010
期刊： The Journal of heredity
影响因子： --
作者： [Lionikas,Arimantas, Carlborg,Orjan, Lu,Lu, Peirce,JeremyL, Williams,RobertW, Yu,Fushun, Vogler,GeorgeP, McClearn,GeraldE, Blizard,DavidA]
通讯作者： Blizard,DavidA
Genetic architecture of fast- and slow-twitch skeletal muscle weight in 200-day-old mice of the C57BL/6J and DBA/2J lineage.
DOI： 10.1152/physiolgenomics.00103.2003
发表时间： 2003-12
期刊： Physiological genomics
影响因子： 4.6
作者： [A. Lionikas;A. Lionikas;D. Blizard;D. Vandenbergh;Marcus G. Glover;J. T. Stout;G. Vogler;G. Mcclearn;L. Larsson;Lars Larsson]
通讯作者： A. Lionikas;A. Lionikas;D. Blizard;D. Vandenbergh;Marcus G. Glover;J. T. Stout;G. Vogler;G. Mcclearn;L. Larsson;Lars Larsson
Bone, muscle, and physical activity: structural equation modeling of relationships and genetic influence with age.
骨骼、肌肉和身体活动：年龄关系和遗传影响的结构方程模型。
DOI： 10.1359/jbmr.090418
发表时间： 2009
期刊： Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
影响因子： --
作者： [Lang,DeanH, Conroy,DavidE, Lionikas,Arimantas, Mack,HollyA, Larsson,Lars, Vogler,GeorgeP, Vandenbergh,DavidJ, Blizard,DavidA, McClearn,GeraldE, Sharkey,NeilA]
通讯作者： Sharkey,NeilA
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