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CORE--ANIMAL MODEL

CORE--ANIMAL MODEL
核心--动物模型
批准号:
6563313
负责人:
GERALD E MCCLEARN
金额:
$15.75万
依托单位国家:
美国
项目类别:
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-03-01 至 2003-01-31

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中文摘要
翻译
动物模型核心将保持C57/BL/6和DBA/2的种畜 小鼠,22个BXD重组近交系(RI)菌株,最初来自 这些菌株,以及从相同菌株衍生的F2代。 将从这些种群中生产出足够数量的老鼠,以满足 横断面生物标志物评价的统计要求 从大约150天、450天或750天开始。一项额外的 将产生F2群,并将一直保持到自然死亡。 所有的动物都将在一种特定的病原体中出生、饲养和维持- 无障碍设施。该核心还将作为公共资源 因为基因分型也将成为 对所有要进行基因分型的动物进行基因分型 需要,以便提供能够进行检测的相关数据 数量追踪基因座(QTL)。急性淋巴细胞白血病的病理分析 横截面动物也将是这个核心的责任。
英文摘要
The Animal Model Core will maintain breeding stock of C57/BL/6 and DBA/2 mice, of 22 BXD recombinant inbred (RI) strains derived initially from these strains, and of an F2 generation derived from the same strains. Mice will be produced from these stocks in sufficient number to meet the statistical requirements for cross-sectional biomarker assessment beginning at approximately 150, 450, or 750 days of age. An additional F2 group will be produced that will be maintained until natural death. All animals will be born, reared, and maintained in a specific-pathogen- free barrier facility. This Core will also serve as the common resource for the genotyping will also serve as the common resource for the genotyping of all of the subject animals for which genotyping is required, in order to provide the relevant data enabling the detection of quantitative trail loci (QTLs). The pathological analysis of all cross-sectional animals will also be the responsibility of this Core.
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