CORE--ANIMAL MODEL

动物模型核心将保留C57/BL/6和DBA/2的种畜 小鼠，22 BXD重组近交系（RI）最初来自 这些菌株，以及来自相同菌株的F2代。 将从这些储备中生产足够数量的小鼠，以满足 横断面生物标志物评估的统计要求 从大约150、450或750日龄开始。额外 将产生F2组，其将维持至自然死亡。 所有的动物都将在特定的病原体中出生，饲养和维持， 自由屏障设施。这一核心也将作为共同资源， 对于基因分型也将作为共同的资源， 对所有受试动物进行基因分型， 为了提供能够进行检测的相关数据， 数量试验基因座（QTL）。所有的病理分析 横截面动物也将是该核心的责任。

The Animal Model Core will maintain breeding stock of C57/BL/6 and DBA/2 mice, of 22 BXD recombinant inbred (RI) strains derived initially from these strains, and of an F2 generation derived from the same strains. Mice will be produced from these stocks in sufficient number to meet the statistical requirements for cross-sectional biomarker assessment beginning at approximately 150, 450, or 750 days of age. An additional F2 group will be produced that will be maintained until natural death. All animals will be born, reared, and maintained in a specific-pathogen- free barrier facility. This Core will also serve as the common resource for the genotyping will also serve as the common resource for the genotyping of all of the subject animals for which genotyping is required, in order to provide the relevant data enabling the detection of quantitative trail loci (QTLs). The pathological analysis of all cross-sectional animals will also be the responsibility of this Core.