QUANTITATIVE TRAIT LOCI AND LONGEVITY

本项目的重点是数量性状基因座的分析 （QTL）与寿命或长寿相关，作为一种表型， 衰老虽然先前的研究结果表明， 这些研究的结果表明，长寿的遗传率约为0.30， 可能会被病毒病原体混淆，因此表明遗传 而不是长寿。本研究 将为480只动物（10 雄性和雌性各10只，22种RI菌株和2种祖菌株） 在他们的一生中。为了跟踪未来的尸检 检查，将在整个过程中定期检查动物 这一天，在很短的时间内， 以防止或最小化自溶。基于RI的QTL分析 应变平均值将寿命与基因型应变分布相关联 模式. RI的固定基因型的一个优点是， 允许在生物标志物表型之间引用关系 在其他RI样本中测量的寿命，提供相关性 标记变量和寿命之间的关系。

The focus of this project is on the analysis of quantitative trait loci (QTLs) associated with length of life, or longevity, as a phenotype of aging. Although previous findings suggest that the upper range of heritability of longevity is about 0.30, the findings from these studies may be confounded by viral pathogens and so indicate genetic predisposition to disease rather than longevity. In this study, a pathogen-free barrier environment will be provided for 480 animals (10 males and 10 females, each of 22 RI stains and 2 progenitor strains) throughout their lives. In order to follow future post-mortem examination, animals will be examined at regular intervals throughout the day to retrieve individuals within a short time of expiration in order to prevent or minimize autolysis. QTL analysis based on the RI strain means will relate longevity to the genotypic strain distribution patterns. An advantage of the fixed genotype of the RIs is that it will allow relationships to be adduced between the biomarker phenotypes measured in other RI samples to that of longevity, providing correlation between the marker variables and length of life.