QUANTITATIVE TRAIT LOCI AND LONGEVITY

本项目的重点是数量性状基因座的分析 (QTL)与寿命长短或长寿有关，如 衰老。尽管之前的研究结果表明， 这些研究发现，长寿的遗传率约为0.30 可能受到病毒病原体的干扰，因此表明基因 容易生病，而不是长寿。在这项研究中，一个 将为480只动物(10只)提供无病原体屏障环境 男性和10名女性，22个RI菌株和2个祖系各1个) 在他们的一生中。为了跟踪未来的尸检 检查，动物将在整个过程中定期进行检查 中的短时间内检索个人的日期 以防止或最大限度地减少自溶。基于RI的QTL分析 菌株均值将把寿命与基因类型的菌株分布联系起来。 模式。RIS固定基因的一个优点是它将 允许引用生物标记物表型之间的关系 在其他RI样本中测量到的寿命，提供了相关性 标记变量和寿命之间的关系。

The focus of this project is on the analysis of quantitative trait loci (QTLs) associated with length of life, or longevity, as a phenotype of aging. Although previous findings suggest that the upper range of heritability of longevity is about 0.30, the findings from these studies may be confounded by viral pathogens and so indicate genetic predisposition to disease rather than longevity. In this study, a pathogen-free barrier environment will be provided for 480 animals (10 males and 10 females, each of 22 RI stains and 2 progenitor strains) throughout their lives. In order to follow future post-mortem examination, animals will be examined at regular intervals throughout the day to retrieve individuals within a short time of expiration in order to prevent or minimize autolysis. QTL analysis based on the RI strain means will relate longevity to the genotypic strain distribution patterns. An advantage of the fixed genotype of the RIs is that it will allow relationships to be adduced between the biomarker phenotypes measured in other RI samples to that of longevity, providing correlation between the marker variables and length of life.