GENERAL BIOMARKERS

该项目将评估小鼠年龄的各种生物标记物 大约150、450和750的行为和生理领域 年龄的天数。这些措施是在以下基础上选择的 除了会面外，还表现出年龄相关性和遗传影响 生物特征充分性和最小压力的标准。大多数措施 在之前的一项研究计划中受雇于量化 老化生物标志物的遗传学，这提供了一个有价值的解释 关于衰老的特定数量遗传学新结果的背景 生物标志物，提供了有价值的解释背景 特异数量性状座位(QTL)的新结果。其中包括 力量和协调性、活动度、尿液渗透压、血液的测量 血压和几项临床血液指标。 将被使用的动物属于两个基因定义的群体：BxD 来自C57BL/6和DBA/2的重组近交系(RI)菌株 品系和F2代动物来自相同的祖代。每个小组都有 多阶段方法的独特优势和局限性 QTL的识别和验证，并共同提供了一个有利的 识别真实QTL并将其排除在考虑之外的策略 假阳性指征。

This project will assess a variety of biomarkers of age in mice from the domains of behavior and physiology at approximately 150, 450, and 750 days of age. These measures have been selected on the basis and demonstrated age-relevance and genetic influence in addition to meeting standards of biometric adequacy and minimal stress. Most of the measures were employed in a previous research program on the quantitative genetics of aging biomarkers, which provides a valuable interpretational context for the new results on specific quantitative genetics of aging biomarkers, which provides a valuable interpretational context for the new results on specific quantitative trait loci (QTLs). Included are measures of strength and coordination, activity, urine osmolality, blood pressure, and several clinical blood measures. The animals to be employed are of two genetically defined groups: BXD recombinant inbred (RI) strains derived from C57BL/6 and DBA/2 inbred strain and F2 animals derived from the same progenitors. Each group has particular advantages and limitations in the multiple-stage approach to QTL identification and verification, and together offer an advantageous strategy for identifying true QTLs and eliminating from consideration false-positive indications.