CORE--VIROLOGY FACILITY

核心——病毒学设施

• 批准号: 6232843
• 负责人: F BLAINE HOLLINGER
• 金额: $ 10.87万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-04-01 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6232843
• 关键词: AIDS; AIDS /HIV test; biomedical facility; clinical research; human immunodeficiency virus 1; human tissue; method development; microorganism culture; tissue resource /registry; training; virus DNA; virus RNA; virus classification

The overall objectives of the Virology Core Laboratory are to provide comprehensive virologic tests and services relevant to HIV research, to make available its specialized BSL2/3 laboratory facilities to HW researchers, and to develop new virologic tests that may be useful in clinical and basic research. Major core services include: (1) assays of HW infectivity by means of quantitative micrococultures, (2) assays of HW1 RNA and DNA, (3) characterization of HIV quasispecies, (4) phenotypic characterization of drug resistance and of syncytium-inducing capacity, and (5) processing, storage and shipment of blood specimens and other biological samples from patients with HIV. The core will also provide training and technical advice to researchers interested in developing sophisticated virologic procedures for their HW projects.

病毒学核心实验室的总体目标是提供与HIV研究相关的全面病毒学测试和服务，向HW研究人员提供其专门的BSL2/3实验室设施，并开发可能对临床和基础研究有用的新病毒学测试。主要核心服务包括：(1) 通过定量微培养法测定 HW 感染性，(2) HW1 RNA 和 DNA 测定，(3) HIV 准种的表征，(4) 耐药性和合胞体诱导能力的表型表征，以及 (5) HIV 患者血液样本和其他生物样本的处理、储存和运输。 该核心还将为有兴趣为其硬件项目开发复杂病毒学程序的研究人员提供培训和技术建议。