HEPATITIS C VIRUS

丙型肝炎病毒

• 批准号: 7598630
• 负责人: F BLAINE HOLLINGER
• 金额: $ 0.81万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7598630
• 关键词: Autoimmune Diseases; Blood; Chronic; Chronic Hepatitis; Computer Retrieval of Information on Scientific Projects Database; Desire for food; Development; Enzymes; Fatigue; Funding; Grant; Hepatitis; Hepatitis C; Hepatitis C Antibodies; Hepatitis C virus; Human; Infection; Injury; Institution; Liver; Liver Cirrhosis; Modeling; Molecular; Molecular Structure; Patients; Population; Primary carcinoma of the liver cells; Research; Research Personnel; Resources; Source; Staging; Symptoms; United States National Institutes of Health; Virus; env Gene Products; liver infection; pathogen; receptor; three dimensional structure

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HCV is a blood born pathogen that infects about 3% of the human population. More than 70% of people infected with the virus eventually get chronic hepatitis which can cause cirrhosis of the liver, hepatocellular carcinoma, autoimmune diseases, and almost 30 other associations. Initially, HCV infection is asymptomatic. After 20-30 years of infection, most of patients will have symptoms (fatigue and poor appetite) of chronic liver infection with elevated levels of liver enzymes such as AST and ALT 1) Determine the 3D structure of hepatitis C virus (HCV) and its molecular components by cryo-EM using infectious blood collected during the early stages of infection prior to the development of liver injury or specific anti-HCV antibody 2) Analyze the molecular structure of the envelope proteins, E1E2, and develop a model of interaction with cellular receptors.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 HCV 是一种血源性病原体，感染约 3% 的人口。 超过 70% 的病毒感染者最终会患上慢性肝炎，从而导致肝硬化、肝细胞癌、自身免疫性疾病以及近 30 种其他疾病。最初，HCV 感染是无症状的。感染20-30年后，大多数患者会出现慢性肝脏感染的症状（疲劳和食欲不振），并伴有AST和ALT等肝酶水平升高 1) 使用在肝损伤或特异性抗 HCV 抗体出现之前的感染早期阶段收集的感染性血液，通过冷冻电镜确定丙型肝炎病毒 (HCV) 及其分子成分的 3D 结构 2) 分析包膜蛋白E1E2的分子结构，并开发与细胞受体相互作用的模型。