POLYUNSATURATED PHOSPHOLIPIDS IN MEMBRANE FUNCTION
膜功能中的多不饱和磷脂
基本信息
- 批准号:6219724
- 负责人:
- 金额:$ 7.46万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1999
- 资助国家:美国
- 起止时间:1999-05-01 至 2000-04-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
We have had a long-standing interest in membrane phosphoglycerides
that contain esterified fatty acids with 4 to 6 cis double bonds.
These fatty acids are members of families of polyunsaturated fatty
acids that cannot be formed de novo by primates or other vertebrates,
and must be provided in the diet if these animals are to reproduce,
develop, grow, and maintain their health. The fatty acids also are of
interest because they are subject to artifactual oxidation and to
special mechanisms to prevent this oxidation and repair its effects,
and there is reason to believe that disorders of these mechanisms
occur in aged individuals, in atherosclerosis, and in
neurodegenerative diseases such as Alzheimer's disease, Parkinson's
disease, and amyotrophic lateral sclerosis. We have been exploring
the possibility that phosphoglycerides that contain polyunsaturated
fatty acids with four or more cis double bonds may normally have an
important structural effect on the nerve plasm a membrane lipid
bilayer. We are in the process of completing detailed molecular
modeling studies to identify factors that might influence the ability
of the phosphoglycerides to interact with each other in simulated
monolayers. We have almost completed an experimental study of the
packing of these phosphoglycerides in monolayers. Experiments with
unilamellar vesicles containing the phosphoglycerides are underway,
and experiments with macaque brain prefrontal cortex synaptosome
plasma membranes and synaptic vesicles (see above) are planned.
FUNDING NIH grant RR00166 and the Howard Hughes Medical Institute.
[This project was also reported in the Neuroscience Core section.]
长期以来,我们一直对细胞膜磷酸甘油酯感兴趣。
含有具有4-6个顺式双键的酯化脂肪酸。
这些脂肪酸是多不饱和脂肪家族的成员。
灵长类或其他脊椎动物不能从头形成的酸,
如果这些动物要繁殖,就必须在饮食中提供,
发展、成长和维持他们的健康。脂肪酸也是
兴趣,因为它们受到人为氧化的影响,并且
防止这种氧化并修复其影响的特殊机制,
有理由相信,这些机制的紊乱
发生在老年人、动脉粥样硬化和
神经退行性疾病,如阿尔茨海默病、帕金森氏症
疾病和肌萎缩侧索硬化症。我们一直在探索
含有多不饱和的磷酸甘油酯
含有四个或四个以上顺式双键的脂肪酸通常具有
神经质a膜脂的重要结构作用
双层的。我们正在完成详细的分子研究
建模研究以确定可能影响能力的因素
磷酸甘油酯在模拟实验中相互作用
单层。我们已经基本完成了一项实验研究
将这些磷酸甘油酯包装在单层中。实验:
含有磷酸甘油酯的单层囊泡正在形成中,
对猕猴大脑前额叶皮质突触体的实验
质膜和突触小泡(见上)是计划好的。
资助美国国立卫生研究院拨款RR00166和霍华德·休斯医学研究所。
[《神经科学核心》栏目也报道了这个项目。]
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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John A. Glomset其他文献
The plasma lecithin:cholesterol acyltransferase reaction
- DOI:
10.1016/s0022-2275(20)43114-1 - 发表时间:
1968-03-01 - 期刊:
- 影响因子:
- 作者:
John A. Glomset - 通讯作者:
John A. Glomset
John A. Glomset的其他文献
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{{ truncateString('John A. Glomset', 18)}}的其他基金
POLYUNSATURATED PHOSPHOLIPIDS IN MEMBRANE FUNCTION
膜功能中的多不饱和磷脂
- 批准号:
6219614 - 财政年份:1999
- 资助金额:
$ 7.46万 - 项目类别:
POLYUNSATURATED PHOSPHOLIPIDS IN MEMBRANE FUNCTION
膜功能中的多不饱和磷脂
- 批准号:
6116298 - 财政年份:1999
- 资助金额:
$ 7.46万 - 项目类别:
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