POLYUNSATURATED PHOSPHOLIPIDS IN MEMBRANE FUNCTION
膜功能中的多不饱和磷脂
基本信息
- 批准号:6116298
- 负责人:
- 金额:$ 8.67万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1999
- 资助国家:美国
- 起止时间:1999-05-01 至 2000-04-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The membranes of neurons contain very high concentrations of special phosphoglycerides that are not found in most other cells. These phosphoglycerides contain esterified "omega 3" unsaturated fatty acids that have 6 cis double bonds. The phosphoglycerides probably have a special function, but that function has yet to be defined. They also may contribute to diseases such as Alzheimer's because they are unusually susceptible to oxidation. We have been exploring the possibility that the phosphoglycerides may have unusual packing properties which are required for effective electrical signaling. Molecular modeling studies, done several years ago in our laboratory, raised the possibility that the phosphoglycerides may interact to form regular, tightly packed arrays. However, direct physical evidence in support of this possibility is still lacking. Comparable phosphoglycerides are not commercially available, so we have had to isolate them from native tissues. This has been a very time-consuming process, but we have obtained promising results that are consistent with the kind of tight molecular packing arrangements that were predicted by our models. When completed, our study should increase our understanding of the molecular basis of neuronal conduction.
神经元的膜含有非常高浓度的特殊磷酸甘油酯,这在大多数其他细胞中是没有的。 这些磷酸甘油酯含有酯化的“ω 3”不饱和脂肪酸,其具有6个顺式双键。 磷酸甘油酯可能有一个特殊的功能,但这种功能还没有被定义。 它们也可能导致阿尔茨海默氏症等疾病,因为它们对氧化异常敏感。 我们一直在探索磷酸甘油酯可能具有有效电信号所需的不寻常的包装特性的可能性。 几年前在我们实验室进行的分子模拟研究提出了磷酸甘油酯可能相互作用形成规则的紧密排列的可能性。 然而,支持这种可能性的直接实物证据仍然缺乏。 可比较的磷酸甘油酯没有商业上可获得的,所以我们不得不从天然组织中分离它们。 这是一个非常耗时的过程,但我们已经获得了有希望的结果,与我们的模型预测的紧密分子堆积排列一致。 完成后,我们的研究应该增加我们对神经元传导的分子基础的理解。
项目成果
期刊论文数量(0)
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科研奖励数量(0)
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John A. Glomset其他文献
The plasma lecithin:cholesterol acyltransferase reaction
- DOI:
10.1016/s0022-2275(20)43114-1 - 发表时间:
1968-03-01 - 期刊:
- 影响因子:
- 作者:
John A. Glomset - 通讯作者:
John A. Glomset
John A. Glomset的其他文献
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{{ truncateString('John A. Glomset', 18)}}的其他基金
POLYUNSATURATED PHOSPHOLIPIDS IN MEMBRANE FUNCTION
膜功能中的多不饱和磷脂
- 批准号:
6219614 - 财政年份:1999
- 资助金额:
$ 8.67万 - 项目类别:
POLYUNSATURATED PHOSPHOLIPIDS IN MEMBRANE FUNCTION
膜功能中的多不饱和磷脂
- 批准号:
6219724 - 财政年份:1999
- 资助金额:
$ 8.67万 - 项目类别:
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