PARTIAL LIQUID VENTILATION IN NEONATES WITH CONGENITAL DIAPHRAGMATIC HERNIA

本研究的主要假设是，使用部分液体通气（PLV）的肺部管理将导致先天性腹股沟疝（CDH）新生儿患者所需的机械通气时间减少。次要假设包括：1）与使用气体通气（GV）管理的患者相比，使用PLV管理的患者符合体外生命支持标准的频率较低; 2）与GV管理的患者相比，使用PLV管理的患者的生存率将增加; 3）与GV管理的患者相比，使用PLV管理的新生儿CDH患者的气体交换将增加; 4）PLV期间全身血流动力学将不变或改善; 5）与GV相比，PLV期间患有CDH的新生儿患者的静态肺顺应性将增加。

The primary hypothesis of this study is that pulmonary management utilizing partial liquid ventilation (PLV) will result in a reduction in the required time of mechanical ventilation in neonatal patients with congenital diaphragmatic hernia (CDH). The secondary hypothesis include: 1) that patients who are managed with PLV will meet criteria for extracorporeal life support less frequently when compared with those managed with gas ventilation (GV); 2) the survival rate will be increased in those patients treated with PLV when compared to GV; 3) gas exchange will increase in neonatal patients with CDH managed with PLV when compared to those managed with GV; 4) systemic hemodynamics will be unaltered or improved during PLV; 5) static pulmonary compliance will increase in neonatal patients wiht CDH during PLV when compared to GV.