PARTIAL LIQUID VENTILATION IN NEONATES WITH CONGENITAL DIAPHRAGMATIC HERNIA

本研究的主要假设是肺部管理 使用部分液体通气（PLV）将导致减少 新生儿呼吸衰竭患者机械通气时间 先天性腹股沟疝。 次要假设包括：1）接受治疗的患者 PLV将符合体外生命支持（ECLS）标准， 与使用气体通气（GV）的患者相比， 接受PLV治疗的患者的生存率将增加 与GV相比; 3）新生儿患者的气体交换将增加 与GV治疗的CDH患者相比，PLV治疗的CDH患者; 3） 在PLV期间，全身血流动力学将保持不变或得到改善; 4）静态 新生儿CDH患者的肺顺应性将增加， 与GV相比，PLV。 到目前为止，我们已经在CHOP招募了7名患者。其中，三个是 随机分为PLV组，4例接受常规治疗。我们目睹 接受PLV治疗的患者的依从性有所改善，但所有7例 患者需要ECMO。

The primary hypothesis of this study is that pulmonary management utilizing partial liquid ventilation (PLV) will result in a reduction in the required time of mechanical ventilation in neonatal patients with congenital diaphragmatic hernia (CDH). The secondary hypotheses include: 1) that patients who are managed with PLV will meet criteria for extracorporeal life support (ECLS) less frequently when compared with those managed with gas ventilation (GV); 2) the survival rate will be increased in those patients treated with PLV when compared to GV; 3) gas exchange will increase in neonatal patients with CDH managed with PLV when compared to those managed with GV; 3) systemic hemodynamics will be unaltered or improved during PLV; 4) static pulmonary compliance will increase in neonatal patients with CDH during PLV when compared to GV. To date we have enrolled 7 patients at CHOP. Of these, three were randomized to PLV and 4 received conventional therapy. We have witnessed improved compliance in the patients who have received PLV, but all 7 patients have required ECMO.