DETERMINANTS OF BASAL FFA FLUX

基础 FFA 通量的决定因素

• 批准号: 6117389
• 负责人: M D JENSEN
• 金额: $ 2.01万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6117389
• 关键词: African American; caucasian American; clinical research; free fatty acids; human subject; lipid transport; obesity; racial /ethnic difference

To compare FFA flux in African-American, Caucasian, lean and obese, and men and women. To determine whether increased plasma FFA delivery is present in conditions which are thought to be pathophysiologically important and examine a fate of FFA once they have exited plasma and entered muscle lipid pools. In collaboration with Doctors Jeanine Albu of St. Lukes-Roosevelt, New York, NY and Samuel Klein of Washington University, St. Louis, MO, these studies are completed. At Mayo Clinic in Rochester we have completed all the studies of Caucasians and have studied one African-American woman and 11 African-American men. Final analysis of samples is currently underway. We appear to have completed this study, although final analysis have not been performed on all samples. All of the Caucasian volunteers proposed for this protocol were studied in Rochester, MN. A number of the African-American volunteers were also studied in Rochester, MN, however, we collaborated with the investigators in St. Louis, MI, and New York, NY, to complete the proposed studies.

比较非裔美国人、高加索人、瘦型和肥胖型以及男性和女性的FFA通量。 确定在被认为具有病理生理学重要性的疾病中是否存在血浆FFA递送增加，并检查FFA离开血浆并进入肌肉脂质池后的命运。这些研究是与纽约州纽约圣卢克-罗斯福的Jeanine Albu博士和密苏里州圣路易斯华盛顿大学的Samuel Klein博士合作完成的。 在罗切斯特的马约诊所，我们完成了对白人的所有研究，并研究了一名非洲裔美国妇女和11名非洲裔美国男子。 目前正在对样品进行最终分析。我们似乎已完成本研究，但尚未对所有样本进行最终分析。 在罗切斯特（MN）对本方案拟定的所有白人志愿者进行了研究。 在明尼苏达州罗切斯特也对一些非洲裔美国志愿者进行了研究，但是，我们与密歇根州圣路易斯和纽约州纽约的研究者合作完成了拟定的研究。