HEPATIC FFA DELIVERY IN NIDDM/HYPERLIPIDEMIA

NIDDM/高脂血症中的肝 FFA 输送

• 批准号: 6117390
• 负责人: M D JENSEN
• 金额: $ 2.01万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6117390
• 关键词: clinical research; free fatty acids; human subject; hyperlipidemia; lipid transport; liver function; noninsulin dependent diabetes mellitus; obesity

The purpose of this study is to determine whether the liver is exposed to excessive amounts of fat present in the bloodstream in obese and non-obese individuals with and without noninsulin-dependent diabetes mellitus. The results of the study indicate that hepatic FFA delivery is increased in obesity, but that visceral fat plays a significant role in increasing hepatic FFA delivery primarily in obese women. We found a positive correlation between visceral fat mass and the percentage of FFA delivered to the liver from visceral lipolysis in women, but did not find this relationship in men. The positive results from this study were important preliminary data for the competing renewal for DK 40484. We believe we have completed volunteer recruitment for this study. The weight loss portion of this study that included a randomized, placebo-controlled, blinded assignment of overweight volunteers to fenfluramine/phentermine was discontinued because of valvular heart disease. All volunteers have been removed from the medication and are being followed with echocardiography. Results of the studies have been analyzed. Pending the completion of animal studies to validate the model we used to estimate hepatic FFA delivery, the results of the studies will be submitted for publication.

本研究的目的是确定患有或不患有非胰岛素依赖型糖尿病的肥胖和非肥胖个体的肝脏是否暴露于血液中过量的脂肪。研究结果表明，肥胖患者的肝脏 FFA 输送量增加，但内脏脂肪在增加肝脏 FFA 输送量方面发挥着重要作用，主要是在肥胖女性中。 我们发现女性内脏脂肪量与内脏脂肪分解输送到肝脏的 FFA 百分比之间存在正相关性，但在男性中没有发现这种关系。 这项研究的积极结果是 DK 40484 竞争更新的重要初步数据。我们相信我们已经完成了这项研究的志愿者招募。 这项研究的减肥部分包括对超重志愿者进行随机、安慰剂对照、盲法分配，使用芬氟拉明/芬特明，但由于瓣膜性心脏病而中止。 所有志愿者均已停止用药，并接受超声心动图检查。 对研究结果进行了分析。 在动物研究完成以验证我们用于估计肝脏 FFA 输送的模型之前，研究结果将提交发表。