INSULIN REGULATION OF REGIONAL FFA METABOLISM

胰岛素对区域 FFA 代谢的调节

• 批准号: 6264982
• 负责人: M D JENSEN
• 金额: $ 2.01万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6264982
• 关键词: clinical research; fatty acid metabolism; free fatty acids; hormone regulation /control mechanism; human subject; insulin; obesity

Abnormalities of fatty acid metabolism are considered to be important contributors to the adverse health consequences of upper body/visceral obesity. We propose to assess the effects of insulin on splanchnic FFA metabolism in visceral obesity and to investigate intramuscular fatty acid kinetics using newly developed stable isotope methodology. The objective of this protocol is to improved insulin action with respect to glucose metabolism, whether accomplished by exercise training/weight loss or via troglitazone treatment is associated with improvements in insulin action on FFA and intramuscular fatty acid metabolism in viscerally obese humans. We have completed a significant number of studies relating to this protocol. 24 of the proposed 32 volunteers have been studied. So far, all studies have been successful.

脂肪酸代谢异常被认为是导致上身/内脏肥胖的不良健康后果的重要因素。 我们建议评估胰岛素对内脏型肥胖患者内脏FFA代谢的影响，并使用新开发的稳定同位素方法研究肌内脂肪酸动力学。 本方案的目的是改善胰岛素对葡萄糖代谢的作用，无论是通过运动训练/体重减轻还是通过曲格列酮治疗实现，均与胰岛素对内脏性肥胖患者FFA和肌内脂肪酸代谢作用的改善相关。我们已经完成了大量与该方案有关的研究。 32名志愿者中的24名已接受研究。 到目前为止，所有的研究都是成功的。