AIDS WASTING IN WOMEN--ANABOLIC EFFECTS OF TESTOSTERONE TREATMENT STUDY

本研究的目的是确定：1）艾滋病消耗综合征（AWS）中雄激素缺乏的病理生理学，2）雄激素缺乏对AWS女性身体成分的影响，3）睾酮对AWS女性瘦体重和生活质量的治疗效果。迄今为止的进展如下，调查人员已筛查了12名艾滋病毒感染妇女，并招募了8名。 在艾滋病毒感染的妇女中，雄激素缺乏的程度很大。 患者的平均年龄为38.9 ± 1.3岁（+ ISEM），IBW百分比为94.1 ± 3.1%。 重量损失百分比为18.8 ± 2.6%。 总睾酮和游离睾酮水平与正常相比分别降低18.9 ± 2.4 ng/dl和0.9 ± 0.1 pg/ml（正常分别为10-5.5 ng/dl和1.1 - 6.3 pg/ml; p<0.0001，相对于游离睾酮的正常平均值。

The purpose of this study is to define: 1) the pathophysiology of androgen deficiency in the AIDS wasting syndrome (AWS), 2) the effects of androgen deficiency on body composition among women with the AWS, and 3) the treatment effects of testosterone on lean body mass and quality of life among women with the AWS. Progress to date is as follows, the investigators have screened 12 HIV infected women and enrolled 8. A significant degree of androgen deficiency was seen among HIV infected women. Patients have a mean age of 38.9 + 1.3 years (+ ISEM) with a percent IBW of 94.1 + 3.1 percent. The percent weight loss was 18.8 + 2.6 percent. Total and free testosterone levels were decreased compared to normal at 18.9 + 2.4 ng/dl and 0.9 + 0.1 pg/ml respectively (normal 10-5.5 ng/dl and 1.1 - 6.3 pg/ml respectively; p<0.0001 vs normal mean for free testosterone.