AIDS WASTING IN WOMEN--ANABOLIC EFFECTS OF TESTOSTERONE TREATMENT STUDY

本研究的目的是确定：1)艾滋病消瘦综合征（AWS）雄激素缺乏的病理生理机制，2)雄激素缺乏对AWS女性身体组成的影响，以及3)睾酮对AWS女性瘦体重和生活质量的治疗作用。迄今为止的进展情况如下：调查人员筛选了12名感染艾滋病毒的妇女，并登记了8名妇女。在感染艾滋病毒的妇女中，雄激素严重缺乏。患者平均年龄为38.9 + 1.3岁（+ ISEM）， IBW为94.1 + 3.1%。体重减轻的百分比为18.8% + 2.6%。与正常相比，总睾酮和游离睾酮水平分别下降18.9 + 2.4 ng/dl和0.9 + 0.1 pg/ml（正常10-5.5 ng/dl和1.1 - 6.3 pg/ml）；与正常平均游离睾酮相比，p<0.0001。

The purpose of this study is to define: 1) the pathophysiology of androgen deficiency in the AIDS wasting syndrome (AWS), 2) the effects of androgen deficiency on body composition among women with the AWS, and 3) the treatment effects of testosterone on lean body mass and quality of life among women with the AWS. Progress to date is as follows, the investigators have screened 12 HIV infected women and enrolled 8. A significant degree of androgen deficiency was seen among HIV infected women. Patients have a mean age of 38.9 + 1.3 years (+ ISEM) with a percent IBW of 94.1 + 3.1 percent. The percent weight loss was 18.8 + 2.6 percent. Total and free testosterone levels were decreased compared to normal at 18.9 + 2.4 ng/dl and 0.9 + 0.1 pg/ml respectively (normal 10-5.5 ng/dl and 1.1 - 6.3 pg/ml respectively; p<0.0001 vs normal mean for free testosterone.