PREVALENCE AND METABOLIC CONSEQUENCES OF RELATIVE GROWTH HORMONE DEFICIENCY IN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 肥胖者生长激素(GH)分泌减少，GH分泌减少与颈动脉内膜厚度增加和炎性心血管(CV)风险标记物相关。还没有研究评估生长激素分泌的相对减少是否独立地导致腹型肥胖患者心血管疾病的增加。 我们假设，相对生长激素缺乏与内脏过度肥胖有关，并在传统危险因素之外，导致腹型肥胖患者心血管风险增加。我们将调查以下假设： 1.相对生长激素缺乏，即生长激素刺激反应不足，将在腹型肥胖症患者中非常普遍，并伴随内脏过度肥胖、游离脂肪酸升高、炎症标志物增加和脂肪细胞因子改变。2腹型肥胖和相对生长激素缺乏患者的颈动脉内膜中层厚度明显高于腹型肥胖和生长激素分泌正常的患者。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Growth hormone (GH) secretion is reduced in obesity and reduced GH secretion is associated with increased carotid intima-medical thickness and inflammatory cardiovasculare (CV) risk markers. No studies have assessed whether relative reductions in GH secretion contribute independently to increased CV disease in patients with abdominal obesity. We hypothesize that a relative growth hormone deficiency is seen in relationship to excess visceral adiposity and contributes to increased cardiovascular risk in patients with abdominal obesity, above and beyond traditional risk factors. The following hypotheses will be investigated: 1. Relative GH deficiency, as defined by inadequate stimulatory responses of GH, will be highly prevalent among patients with abdominal obesity, in association with excess visceral adiposity, elevated free fatty acids, increased inflammatory markers and altered adipocytokines. 2 Carotid IMT will be increased among patients with abdominal obesity and relative GH deficiency compared to patients with abdominal obesity and adequate GH secretion.