LONG-TERM PHYSIOLOGIC EFFECTS OF GH IN HIV LIPODYSTROPHY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们假设，对患有HIV脂肪营养不良的生长激素缺乏患者进行长期的生理性GH治疗，将改善胰岛素敏感性、心血管风险参数、骨密度和身体成分。 在一项随机、双盲、安慰剂对照的研究中，我们将确定： A)长期服用生理性生长激素对体成分、骨密度和骨转换指标、心血管危险指标(包括传统的血脂水平和增加心血管风险的新炎症标志物)和血糖稳态的影响； 2)停用生长激素后，生理性生长激素治疗效果是否持续。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We hypothesis that long-term, physiologic GH administration to GH deficient patients with HIV lipodystrophy, defined based on responses to standardized stimulation testing, will improve, insulin sensitivity, cardiovascular risk parameters, bone density and body composition. In a randomized, double-blinded, placebo-controlled study, we will determine: A)The effects of long-term physiologic GH dosing on body composition, bone density and markers of bone turnover, CV risk markers including traditional lipid levels and novel inflammatory marker of increased CV risk, and glucose homeostasis; B)Whether the effects of physiologic GH treatment are sustained after GH withdrawal.