A new BTB-ZF family transcription factor required in development and dysregulated in malignant disease

恶性疾病发育和失调所需的新 BTB-ZF 家族转录因子

• 批准号: nhmrc : 637395
• 负责人: Prof Graham Lieschke
• 金额: $ 29.33万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/new-btb-zf-malignant-disease/96201
• 关键词: new; BTB; ZF; family; transcription

We are studying the function and biology of a novel gene that looks like a generegulator. We generated a zebrafish mutant with defective myeloid development, and we found this gene causes the defect. This mutant fish provides a handle on the biological function of the gene in development. This gene has the hallmarks of a transcription factor and we will study how it regulates other genes, and how it may be a target for treatment of several cancers in which expression of this gene is activated.

我们正在研究一种看起来像遗传基因的新基因的功能和生物学。我们产生了一个有髓系发育缺陷的斑马鱼突变体，我们发现这个基因导致了这种缺陷。这种突变的鱼提供了该基因在发育过程中的生物学功能的句柄。该基因具有转录因子的特征，我们将研究它如何调节其他基因，以及它如何成为治疗该基因表达被激活的几种癌症的靶点。