TIMED BREEDING STUDIES IN MACAQUES

这是对其他调查人员服务的延续， 提供已知胎龄的妊娠并监测胎儿 恒河猴（Macaca mulatta）。 猴子的周期是 通过每日注射孕酮（5 mg/天）控制10 天 雌性在最后一次交配后的第14至21天与雄性配对。 黄体酮注射液 排卵和受孕发生在第16天， 注射孕酮后18小时。 成功率，基于可行 妊娠21天的胎儿，在第一个周期保持在60%至70% 交配 胎儿的发育是通过每周的超声波检查来监测的 直到分娩的时候。 在每次考试中， 根据胎龄，为了确定孕囊长度， 头臀长、心率、股骨长和双股径。 对胎盘盘进行评估以确定任何 异常 这些程序使调查人员能够 在特定的妊娠阶段进行研究，并确定 对胎儿的影响。

This is a continuation of services to other investigators to provide pregnancies of known gestational ages and to monitor fetal growth in rhesus monkeys (Macaca mulatta). The monkeys' cycles are controlled by the daily injection of progesterone (5 mg/day) for 10 days. Females are paired with males on days 14 to 21 after the last progesterone injection. Ovulation and conception occurs on day 16 to 18 after the progesterone injections. Success rate, based on viable fetus at 21 days gestation, remains at 60% to 70% for first cycle matings. Fetal development is monitored by weekly ultrasound exams until time of parturition. At each exams measurements at taken, depending on gestational age, to determine gestational sac length, crown-rump length, heart rate, femur length, and bipartial diameter. Evalualtion of the placental disks are made to determine any anomalies. These procedures provide investigators with the ability to conduct studies at specific stages of gestation and to determine any effects on the fetuses.