CYCLE SYNCHRONIZATION IN RHESUS MONKEYS

作为一项服务，我们提供了一种周期同步的方法和 按照其他研究者的要求延长黄体期。这些 调查人员要求一群雌性恒河猴在 正常月经周期的黄体中期，都在同一天，所以 同样的病毒疫苗也可以用于阴道接种。 这种同步提供如下所示：观察猴子 每天检查是否有月经迹象。当它发生时，每只猴子都会 从周期的第16天开始注射黄体酮。当所有 研究猴子已经接受了至少8天的黄体酮 注射停止了。月经发生在月经的最后2-3天 黄体酮注射。在这个周期的第16天，猴子们开始了一个 第二轮黄体酮注射。接种已经完成了 在最后一系列黄体酮治疗中的某一天。这 程序提供了10只或更多猴子的研究小组，所有 在他们的周期阶段同步+1天，并维持在黄体中 舞台最多可容纳21人

We provide, as a service, a method for cycle synchronization and prolonged luteal phase as required by other investigators. These investigators require that a group of female rhesus monkeys be in the mid-luteal phase of a normal menstrual cycle, all on the same day, so that the same virus inoculums could be used for vaginal inoculation. This synchronization is provided as follows The monkeys are observed daily for indications of menses. When it occurs, each monkey is then injected with progesterone starting on day 16 of that cycle. When all study monkeys have received at least 8 days of progesterone the injections are stopped. Menses occurs 2-3 days of the last progesterone injection. On day 16 of that cycle the monkeys began a second series of progesterone injections. The inoculations are done on a single day during this last series of progesterone. This procedure has provided study groups of 10 or more monkeys, all synchronized + 1 day in their cycle stage and maintained in a luteal stage for up to 21