TIMED BREEDING CORE

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。杜兰国家灵长类动物研究中心的定时繁殖计划使用外源性黄体酮来控制排卵时间。超声波检查是在雌性与雄性放置以确定妊娠后24或31天进行的。该程序允许有效地使用男性，并且通常在24小时的时间范围内提供受孕日期。在2004-2005年繁殖季节，33只印度恒河猴被繁殖，导致4只怀孕。其中两次妊娠导致胎儿死亡。另外两名婴儿被分配到项目检查（1）母亲疟疾对胎儿发育和婴儿生长的影响，（2）新生儿SIV感染的影响。在过去的25年里，通过黄体酮给药控制排卵后的妊娠率超过60%。在上一次基础赠款续延实地考察期间提出的建议要求改变激素的供应和稀释激素的油，新试剂由于溶解度低而造成问题，此外，饲养安排也有重大变化，一些雌性仍在哺乳。这些因素很可能是导致怀孕率下降的原因。 在2005-2006年的繁殖季节，切换到人类孕酮和21个黄金繁殖年龄的女性已经繁殖的时间。目前，已知有4例怀孕，15例待确定。在这个季节生产的婴儿将被分配到一个项目，检查新生儿SIV感染的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The timed-breeding program at the Tulane National Primate Research Center uses exogenous progesterone administration to control the time of ovulation. Ultrasonography is performed 24 or 31 days after placing the female with the male to establish pregnancy. This procedure allows for efficient use of the males and generally provides a conception date within a 24 hour time frame. In the 2004-2005 breeding season, 33 Indian-origin rhesus monkeys were bred resulting in 4 pregnancies. Two of the pregnancies resulted in fetal deaths. The other two infants were assigned to projects examining (1) effects of maternal malaria on fetal development and infant growth, and (2) effects of neonatal SIV infection. Over the past 25 years, the pregnancy rate following controlled ovulation through progesterone administration has been in excess of 60%. Recommendations made during the last Base Grant renewal site visit necessitated a change in the supply of the hormone and the oil used to dilute it. The new reagents posed a problem because of low solubility, moreover there were significant changes in the housing arrangements and several of the females still had nursing infants. It is most likely that these factors were contributing to the reduction in pregnancy rate. In the 2005-2006 breeding season, a switch was made to human progesterone and 21 prime breeding age females have been time bred. At the present time, there are 4 known pregnancies and 15 pending determination. Infants produced in this season will be assigned to a project examining the effects of neonatal SIV infection.