TIMED BREEDING STUDIES IN MACAQUES

我们为其他需要怀孕的调查人员提供服务 已知胎龄的猴子，并监测胎儿的生长， 恒河猴（Macaca mulatta）。 猴子的周期是人为的 通过每日注射以下物质刺激以诱导黄体期 孕酮（5毫克/天）10天。 雌性与雄性配对， 最后一次注射孕酮后14至21天。 过去的研究 表明排卵和受孕发生在排卵后第16至18天， 黄体酮注射 成功率，基于存活胎儿， 妊娠21天，第一周期交配的平均比例为60%至85%， 根据女性的年龄和健康状况。 胎儿发育 通过每周超声波检查进行监测，直至分娩。 在 每次检查测量，根据胎龄， 测定孕囊长度、顶臀长度、心率、股骨 长度和双偏径。 这些测量允许 胎龄和正常生长偏差的测定 参数 对胎盘盘进行评估，以确定 任何异常 这些程序为调查人员提供了 在特定阶段进行研究的能力

We provide a service to other investigators who need pregnant monkeys of known gestational ages and to monitor fetal growth in rhesus monkeys (Macaca mulatta). The monkeys' cycles are artificially stimulated to induce a luteal phase by the daily injection of progesterone (5 mg/day) for 10 days. Females are paired with males on days 14 to 21 after the last progesterone injection. Past studies indicate that ovulation and conception occurs on day 16 to 18 after the progesterone injections. Success rate, based on viable fetus at 21 days gestation, averages from 60% to 85% for first cycle matings, depending on age and health status of the females. Fetal development is monitored by weekly ultrasound exams until time of parturition. At each exam measurements are taken, depending on gestational age, to determine gestational sac length, crown-rump length, heart rate, femur length, and bipartial diameter. These measurements allow for determination of fetal age and of deviations from normal growth parameters. Evaluation of the placental disks are made to determine any anomalies. These procedures provide investigators with the ability to conduct studies at specific stages