IDENTIFICATION OF PATIENTS WITH MULTIPLE ENDOCRINE NEOPLASIA TYPE IIA

IIA 型多发性内分泌肿瘤患者的识别

• 批准号: 6245633
• 负责人: SALLY CARTY
• 金额: $ 1.76万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-18 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6245633
• 关键词: clinical research; early diagnosis; endocrine disorder diagnosis; family genetics; human subject; multiple endocrine neoplasia; neoplasm /cancer diagnosis

The hypothesis tested in this study is that prospective investigation of affected kindreds with multiple endocrine neoplasia (MEN)-IIa, MEN-IIb or FMCT will allow early detection, syndrome delineation & improved survival. The poly-endocrine neoplasms of MEN-II occur in 2 different inherited forms each with age dependent biochemical & clinical penetrance: MEN type IIa (Sipple's Syndrome) & MEN type IIb (multimucosal neurome syndrome). Medullary cancer of the thyroid (MCT), is the most common index lesion of both types.

在这项研究中检验的假设是， 多发性内分泌瘤（MEN）-IIa、MEN-IIb的受累性运动障碍 或禁产条约 将允许早期检测，症状描述和改善 生存MEN-II的多内分泌肿瘤发生在2个不同的 遗传形式，每种形式具有年龄依赖性生化和临床 症状：IIa型MEN（西普尔综合征）和IIb型MEN （多发性神经瘤综合征）。 甲状腺髓样癌 (MCT)是两种类型中最常见的索引病变。