IDENTIFICATION OF PATIENTS WITH MULTIPLE ENDOCRINE NEOPLASIA TYPE IIA AND IIB

IIA 型和 IIB 型多发性内分泌肿瘤患者的识别

• 批准号: 6219198
• 负责人: SALLY CARTY
• 金额: $ 0.3万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6219198
• 关键词: clinical research; early diagnosis; endocrine disorder diagnosis; family genetics; human subject; multiple endocrine neoplasia; neoplasm /cancer diagnosis

The hypothesis tested in this study is that prospective investigation of affected kindreds with multiple endocrine neoplasia (MEN)-IIa, MEN-IIb or FMCT will allow early detection, syndrome delineation & improved survival. The poly-endocrine neoplasms of MEN-II occur in 2 different inherited forms each with age dependent biochemical & clinical penetrance: MEN type IIa (Sipple's Syndrome) & MEN type IIb (multimucosal neurome syndrome). Medullary cancer of the thyroid (MCT) is the most common index lesion of both types.

本研究中检验的假设是，对多发性内分泌瘤（MEN）-IIa、MEN-IIb或FMCT受影响的运动的前瞻性研究将允许早期检测、综合征描述和改善生存率。MEN-II的多内分泌肿瘤以2种不同的遗传形式发生，每种遗传形式具有年龄依赖性生化和临床特征：MEN IIa型（Sipple综合征）和MEN IIb型（多粘液神经瘤综合征）。甲状腺髓样癌（MCT）是两种类型中最常见的索引病变。