Do breast cancer risk factors differ according to underlying genetic susceptibility? A pooled analysis of prospective studies from the NCI Cancer Cohort Consortium

乳腺癌危险因素是否因潜在遗传易感性而异？

• 批准号: nhmrc : 1145771
• 负责人: A/Pr Roger Milne
• 金额: $ 28.3万
• 依托单位: Cancer Council Victoria
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/breast-cancer-risk-cohort-consortium/1320523
• 关键词: Do; breast; cancer; risk; factors

We propose to use data from 23 international prospective cohort studies in the Cancer Cohort Consortium organised by the US National Cancer Institute to evaluate gene environment interactions for women who are at increased genetic risk of breast cancer. Our ultimate goal is to enhance the performance of clinical prediction tools and to develop targeted evidence-based strategies to mitigate the high absolute risk of breast cancer for women at increased genetic risk of the disease.

我们建议使用由美国国家癌症研究所组织的癌症队列联盟的23项国际前瞻性队列研究的数据来评估乳腺癌遗传风险增加的妇女的基因环境相互作用。我们的最终目标是提高临床预测工具的性能，并制定有针对性的循证策略，以减轻遗传风险增加的妇女患乳腺癌的高绝对风险。