Do bone marrow macrophages regulate leukaemia stem cells and their response to treatment?

骨髓巨噬细胞是否调节白血病干细胞及其对治疗的反应？

• 批准号: nhmrc : 1046590
• 负责人: A/Pr Allison Pettit
• 金额: $ 39.35万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/bone-marrow-macrophages-response-treatment/111855
• 关键词: Do; bone; marrow; macrophages; regulate

This project will investigate the role of population of immune cells called macrophages in promoting resistance of leukaemia cells to chemotherapy treatments. As a high proportion of adult patients with acute leukaemia cannot be cured with current treatments, this project could lead to more efficacious therapies targeting macrophages to sensitise leukaemia cells to chemotherapy treatments.

该项目将研究称为巨噬细胞的免疫细胞群体在促进白血病细胞对化疗治疗的抵抗中的作用。由于高比例的成人急性白血病患者无法用目前的治疗方法治愈，该项目可能会导致更有效的治疗靶向巨噬细胞，使白血病细胞对化疗敏感。