Osteal macrophages: novel regulators of osteoblast function and the endosteal stem cell niche

骨巨噬细胞：成骨细胞功能和骨内干细胞生态位的新型调节剂

• 批准号: nhmrc : 519744
• 负责人: A/Pr Allison Pettit
• 金额: $ 27.08万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/osteal-macrophages-novel-cell-niche/115752
• 关键词: Osteal; macrophages; novel; regulators; osteoblast

Bone diseases are a major health problem and current treatments are inadequate. We are investigating a novel role for macrophages (cells important in tissue maintenance and immune responses) in bone growth, repair and disease. Greater understanding of this will provide new ways to treat bone disease. We will also determine if these macrophages help support stem cells that reside near bone surfaces, which may provide new treatment strategies to improve bone marrow transplantation in cancer.

骨骼疾病是一个主要的健康问题，目前的治疗是不够的。我们正在研究巨噬细胞（在组织维护和免疫反应中重要的细胞）在骨骼生长、修复和疾病中的新作用。更好地理解这一点将为治疗骨骼疾病提供新的方法。我们还将确定这些巨噬细胞是否有助于支持驻留在骨表面附近的干细胞，这可能为改善癌症骨髓移植提供新的治疗策略。