Regulation of Bone Dynamics by Osteal Tissue Macrophages (Osteomacs)

骨组织巨噬细胞（Osteomacs）对骨动力学的调节

• 批准号: nhmrc : 631484
• 负责人: A/Pr Allison Pettit
• 金额: $ 49.42万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-bone-dynamics-macrophages-osteomacs/101430
• 关键词: Regulation; Bone; Dynamics; Osteal; Tissue

There is a high demand for effective treatments to rebuild and replace lost bone in fracture repair and osteoporosis. We have described a discrete population of macrophages (classically immune defense cells) within the specialized tissues that line bones. We have shown that these bone tissue macrophages have a novel role in promoting the formation of new bone. This project grant will extend these observations and identify the clinical potential of bone tissue macrophages to treat bone disease.

在骨折修复和骨质疏松症中，对重建和替代丢失的骨的有效治疗有很高的需求。我们已经描述了一个离散的群体巨噬细胞（经典的免疫防御细胞）内的专门组织，内衬骨骼。我们已经证明，这些骨组织巨噬细胞在促进新骨形成方面具有新的作用。该项目赠款将扩展这些观察，并确定骨组织巨噬细胞治疗骨病的临床潜力。