Osteal macrophages as therapeutic targets for fracture repair

骨巨噬细胞作为骨折修复的治疗靶点

• 批准号: nhmrc : 1143802
• 负责人: A/Pr Allison Pettit
• 金额: $ 41.79万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/osteal-macrophages-therapeutic-fracture-repair/1320031
• 关键词: Osteal; macrophages; therapeutic; targets; fracture

Fragility fracture associated with osteoporosis is a substantial health problem costing $1.62 billion to treat in 2012 in Australia. There is no approved therapy to improve and accelerate fracture healing to help reduce this increasing health burden. This research will advance understanding of fracture repair in healthy and osteoporotic bone and progress development of a fracture therapy to improve bone repair by promoting specialised immune cells.

与骨质疏松症相关的脆性骨折是一个严重的健康问题，2012年澳大利亚的治疗费用为16.2亿美元。目前还没有批准的治疗方法来改善和加速骨折愈合，以帮助减轻这种日益增加的健康负担。本研究将促进对健康骨和骨质疏松骨的骨折修复的理解，并推进通过促进特异性免疫细胞来改善骨修复的骨折治疗的发展。