Novel treatment approaches to prevent joint fusion in ankylosing spondylitis

预防强直性脊柱炎关节融合的新治疗方法

• 批准号: nhmrc : 1006450
• 负责人: A/Pr Allison Pettit
• 金额: $ 31.84万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-treatment-approaches-ankylosing-spondylitis/109178
• 关键词: Novel; treatment; approaches; prevent; joint

Ankylosing spondylitis (AS) is a form of arthritis targeting the spine and pelvis that causes uncontrolled bone formation resulting in complete joint fusion, severe disability and even death for which no therapies are currently available. Using a mouse model that closely replicates the human disease we will characterise the changes causing this joint fusion and identify possible new targets to develop novel treatments.

强直性脊柱炎（AS）是一种以脊柱和骨盆为靶点的关节炎，可导致骨形成不受控制，导致关节完全融合、严重残疾甚至死亡，目前尚无治疗方法。使用一个密切复制人类疾病的小鼠模型，我们将研究导致这种关节融合的变化，并确定可能的新靶点，以开发新的治疗方法。