Recipient bone marrow macrophages contribute to haematopoietic stem cell transplantation success

受体骨髓巨噬细胞有助于造血干细胞移植的成功

• 批准号: nhmrc : 1102964
• 负责人: A/Pr Allison Pettit
• 金额: $ 41.76万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/recipient-bone-marrow-transplantation-success/662643
• 关键词: Recipient; bone; marrow; macrophages; contribute

We propose an innovative approach to reduce risk and increase success of blood stem cell transplantation. We will determine whether a specialized cell within the transplant patient is required for donor stem cells to successfully take up residence and recreate the blood and immune system. We will test whether fortifying these specialized cells will improve transplantation outcomes, consequently increasing the number of transplants that can proceed and reducing potentially fatal complications.

我们提出了一种创新的方法来降低风险，提高造血干细胞移植的成功率。我们将确定移植患者体内是否需要一种专门的细胞来使供体干细胞成功地驻留并重建血液和免疫系统。我们将测试强化这些特化细胞是否会改善移植结果，从而增加可以进行的移植数量并减少潜在的致命并发症。