Do the Developmental vitamin D-deficiency and maternal immune activation animal models of schizophrenia have convergent early pathways ?

精神分裂症的发育性维生素 D 缺乏和母体免疫激活动物模型是否具有趋同的早期途径？

• 批准号: nhmrc : 1057883
• 负责人: Prof Darryl Eyles
• 金额: $ 44.65万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/developmental-vitamin-d-early-pathways/454641
• 关键词: Do; Developmental; vitamin; deficiency; maternal

The etiology of schizophrenia is unknown but it is generally considered to have a neurodevelopmental basis and involve altered dopamine signaling. Using two distinct developmental animal models of schizophrenia we have shown convergent gestational abnormalities in how dopamine systems develop. This is possibly a convergent early etiological mechanism in schizophrenia.

精神分裂症的病因尚不清楚，但通常认为它具有神经发育基础，并涉及多巴胺信号的改变。使用两种不同的精神分裂症发育动物模型，我们已经显示了多巴胺系统发育的收敛性妊娠异常。这可能是精神分裂症的一个趋同的早期发病机制。