A new animal model of the prodrome in schizophrenia. Enhanced Dopamine in Prodromal Schizophrenia (EDiPs)

精神分裂症前驱症状的新动物模型。

• 批准号: nhmrc : GNT1124724
• 负责人: Prof Darryl Eyles
• 金额: $ 57.2万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/new-animal-model-schizophrenia-edips/1347431
• 关键词: new; animal; model; prodrome; schizophrenia.

Psychiatrists now recognize a pre-symptomatic stage is present in people at risk of developing schizophrenia. Using new brain imaging techniques we now know that some of these individuals have changes in a major neurotransmitter, dopamine, prior to being diagnosed. We have developed a new model in animals, which recreates these exact same changes at a comparable age. We want to now understand what are the broader effects in the brain and try and block these changes in dopamine with new drugs.

精神科医生现在认识到，有患精神分裂症风险的人存在症状前阶段。使用新的大脑成像技术，我们现在知道其中一些人在被诊断之前，主要神经递质多巴胺就发生了变化。我们在动物身上开发了一种新模型，可以在相当的年龄重现这些完全相同的变化。我们现在想了解大脑中更广泛的影响是什么，并尝试用新药物阻止多巴胺的这些变化。