Maternal vitamin D supplementation in a maternal immune activation model of schizophrenia: mechanisms of prevention

精神分裂症母体免疫激活模型中母体维生素 D 的补充：预防机制

• 批准号: nhmrc : 1124721
• 负责人: Prof Darryl Eyles
• 金额: $ 35.78万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/maternal-vitamin-d-mechanisms-prevention/947422
• 关键词: Maternal; vitamin; supplementation; maternal; immune

Maternal infection and vitamin D deficiency during pregnancy increase the risk of children developing schizophrenia. We model these risk factors in pregnant mice. Offspring produce schizophrenia-like behaviours. When pregnant mice with experimental inflammation are treated with the hormonally active form of vitamin D this completely abolished all schizophrenia-like behaviours in offspring. We want to a) understand this mechanism, b) replicate using a form of vitamin D safe-to-use in humans.

孕妇感染和孕期维生素D缺乏会增加儿童患精神分裂症的风险。我们在怀孕的小鼠身上模拟了这些风险因素。后代会产生类似精神分裂症的行为。当患有实验性炎症的怀孕小鼠接受激素活性形式的维生素D治疗时，这完全消除了后代的所有精神分裂症样行为。我们想要a)了解这一机制，b)在人类中使用一种安全使用的维生素D进行复制。