Maternal vitamin D supplementation in a maternal immune activation model of schizophrenia: mechanisms of prevention

精神分裂症母体免疫激活模型中母体维生素 D 的补充：预防机制

• 批准号: nhmrc : GNT1124721
• 负责人: Prof Darryl Eyles
• 金额: $ 52.34万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/maternal-vitamin-d-mechanisms-prevention/1347429
• 关键词: Maternal; vitamin; supplementation; maternal; immune

Maternal infection and vitamin D deficiency during pregnancy increase the risk of children developing schizophrenia. We model these risk factors in pregnant mice. Offspring produce schizophrenia-like behaviours. When pregnant mice with experimental inflammation are treated with the hormonally active form of vitamin D this completely abolished all schizophrenia-like behaviours in offspring. We want to a) understand this mechanism, b) replicate using a form of vitamin D safe-to-use in humans.

怀孕期间母亲感染和维生素 D 缺乏会增加儿童患精神分裂症的风险。我们在怀孕小鼠中模拟了这些危险因素。后代会产生类似精神分裂症的行为。当患有实验性炎症的怀孕小鼠接受激素活性形式的维生素 D 治疗时，后代中所有类似精神分裂症的行为都被完全消除了。我们想要 a) 了解这一机制，b) 使用人类安全使用的维生素 D 形式进行复制。