Discovery and translation of disease causing mutations with genomic and transcriptomic data

利用基因组和转录组数据发现和转化引起疾病的突变

• 批准号: nhmrc : GNT1102971
• 负责人: Prof Melanie Bahlo
• 金额: $ 62.27万
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/discovery-translation-disease-genomic-transcriptomic/1346253
• 关键词: Discovery; translation; disease; causing; mutations

This proposal will develop and apply methods for the analysis of genetic data generated from family and cohort studies of collaborators to identify genetic risk loci for both neurogenetic disorders and infectious diseases, particularly malaria. The project will combine large-scale datasets of different types and across different species. This will require the development and application of multivariate statistical analysis methods suited to the data.

这项提案将开发和应用分析合作者的家庭和队列研究产生的遗传数据的方法，以确定神经遗传性疾病和传染病，特别是疟疾的遗传风险基因。该项目将结合不同类型和不同物种的大规模数据集。这将需要开发和应用适合这些数据的多变量统计分析方法。