Organoids as Tools for Fundamental Discovery and Translation

摘要 要求支持一次题为“类器官作为基础教育工具”的Keystone专题讨论会。 发现和翻译组织博士杰森斯宾塞，梅丽莎小和芭芭拉Treutlein。的 会议将于2022年4月3日至6日在科罗拉多的Keystone举行。 类器官是复杂的三维体外类器官模型系统。类器官可以来源于 多能干细胞或原代供体组织，并已用于解决以下基本问题： 发育、干细胞生物学和器官再生。人类类器官突出了 人类生物学中的未知数，并对人体器官的细胞构成进行了新的探索 在发育、成年和疾病期间。努力提高类器官系统的复杂性，以及 为了使类器官系统更加强大、可重复和可控，促使人们努力进行基准测试， 体外类器官系统对抗其体内对应物，以及通过以下途径控制类器官系统的努力： 生物工程方法。本次研讨会的目标是突出最近和新兴的进展， 将类器官作为推动生物学若干领域向前发展的工具，包括提高复杂性， 成熟，高含量药物筛选，疾病建模，以及理解发展和进化。我们 预计与会者将从这次会议中获得新的科学知识，新的方法和新的 技术能力。此外，鉴于在基础发现和 翻译研究跨越了广泛的学科，很可能这次会议将汇集一个 多样化的受众，促进新颖的跨学科互动。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Organoids as Tools for Fundamental Discovery and Translation organized by Drs. Jason Spence, Melissa Little and Barbara Treutlein. The conference will be held in Keystone, Colorado from April 3-6, 2022. Organoids are complex three-dimensional in vitro organ-like model systems. Organoids can be derived from pluripotent stem cells or primary donor tissue and have been used to address fundamental questions about development, stem cell biology and organ regeneration. Human organoids have highlighted significant unknowns in human biology and have invigorated new exploration into the cellular makeup of human organs during development, in the adult and during disease. Efforts to improve complexity in organoid systems, and to make organoid systems more robust, reproducible and controlled have prompted efforts to benchmark in vitro organoid systems against their in vivo counterparts, and efforts to control organoid systems through bioengineering approaches. The goals of this symposium are to highlight recent and emerging advances that implement organoids as tools to move several areas of biology forward, including improving complexity and maturation, high content drug screening, disease modeling, and understanding development and evolution. We anticipate that attendees will take away from this meeting new scientific knowledge, new methods and new technical capabilities. Moreover, given that the implementation of organoids in basic discovery and translational research spans a wide range of disciplines, it is likely that this meeting will bring together a diverse audience fostering novel cross-disciplinary interactions.