BODY COMP/CORONARY RISK FACTOR INTERACTIONS IN REHAB OF OLDER CORONARY PTS.

老年冠心病患者康复中身体成分/冠心病风险因素的相互作用。

• 批准号: 6115922
• 负责人: PHILIP A. ADES
• 金额: $ 3.29万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6115922
• 关键词: aerobic exercise; age difference; blood lipid; blood pressure; body composition; clinical research; coronary disorder; disease /disorder proneness /risk; human old age (65+); human subject; insulin; physical fitness; rehabilitation

The goal of this study is to discriminate the effect of exercise training, changes in body composition and changes in dietary intake on coronary risk factors in a coronary population. The study population consisted of 122 patients who had recently suffered a coronary event who were entering the outpatient cardiac rehabilitation program. Data collection included measures of fitness such as peak aerobic capacity, body composition, body fat distribution and measures of coronary risk factors such as lipid profiles, glucose and insulin measures. Before conditioning, it was found that measures of body fat distribution were the best predictors of coronary risk factors in older women with coronary heart disease. In male coronary patients this situation is somewhat different as it was found that in contrast to women, general measures of obesity such as body weight, body mass index and fat mass best predicted coronary risk factors. In response to 3 months of cardiac rehabilitation exercise conditioning males decreased fat mass and waist circumference to a greater degree than women. Both men and women increased their HDL levels whereas other lipid subfractions, glucose and insulin levels were unchanged. Patients with the most abnormal measures of certain lipid subfractions, such as patients with triglyceride values over 250 mg/dL, experienced a significant 25% decrease in this measure after conditioning. Changes in risk factors after conditioning were not closely associated with changes in body composition or body fat distribution.

本研究的目的是区分运动训练、身体成分的改变和饮食摄入的改变对冠心病人群冠状动脉危险因素的影响。研究人群包括122名最近遭受冠状动脉事件的患者，他们正在进入门诊心脏康复计划。数据收集包括健康指标，如峰值有氧能力、身体成分、体脂分布和冠状动脉危险因素指标，如血脂、葡萄糖和胰岛素指标。在调节之前，发现体脂分布的测量是老年冠心病妇女冠状动脉危险因素的最佳预测指标。在男性冠状动脉患者中，情况有所不同，因为研究发现，与女性相比，体重、体重指数和脂肪量等一般肥胖指标最能预测冠状动脉风险因素。在3个月的心脏康复训练后，男性的脂肪量和腰围比女性减少的程度更大。男性和女性的高密度脂蛋白水平都增加了，而其他脂质亚组分、葡萄糖和胰岛素水平没有变化。某些脂质亚组分测量最异常的患者，如甘油三酯值超过250 mg/dL的患者，在调节后该测量显着降低25%。调节后危险因素的变化与身体成分或体脂分布的变化没有密切关系。