BODY COMP/CORONARY RISK FACTOR INTERACTIONS IN REHAB OF OLDER CORONARY PTS.

老年冠心病患者康复中身体成分/冠心病风险因素的相互作用。

• 批准号: 6277156
• 负责人: PHILIP A. ADES
• 金额: $ 2.62万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6277156
• 关键词: aerobic exercise; age difference; blood lipid; blood pressure; body composition; clinical research; coronary disorder; disease /disorder proneness /risk; human old age (65+); human subject; insulin; physical fitness; rehabilitation

In this study, 140 coronary patients have undergone comprehensive evaluations which include exercise stress testing, 24 hour dietary recall, fasting lipid profiles, insulin and glucose levels and dual x-ray absorptiometry. Of these patients, 97 have returned for repeat testing after 3 months of exercise rehabilitation. The primary study hypotheses are:1. Baseline measures of body composition and/or body fat distribution, will predict baseline values of coronary risk factors such as serum triglycerides, HDL-cholesterol, Peak aerobic capacity and fasting insulin levels2. Training induced changes in body composition and/or body fat distribution will predict changes in measures of coronary risk factors such as triglycerides, HDL-cholesterol and fasting insulin levels. Our initial analysis showed that baseline body fat distribution, as measured by the waist to hip ratio (WHR), was the best predictor of serum triglyceride levels, HDL-cholesterol and fasting insulin levels in older women with coronary artery disease, compared with a number of other clinically available measures such as dietary intake of macronutrients. On the other hand, peak aerobic capacity was the best predictor of LDL- cholesterol. We will soon be reanalyzing our data on baseline predictors to include both genders and the entire age spectrum. In addition, we will analyze effects of exercise training on body fat distribution and related coronary risk factors.

在这项研究中，140名冠心病患者接受了全面的 评估包括运动压力测试，24小时饮食回忆， 空腹血脂、胰岛素和血糖水平及双重X光检查 吸光度测定法。在这些患者中，97人已返回进行重复检测 经过3个月的运动康复。主要的研究假设 是：1.身体成分和/或身体脂肪分布的基线测量， 将预测血清等冠状动脉危险因素的基线值 甘油三酯、高密度脂蛋白、峰值有氧能力和空腹胰岛素 2级。训练引起的身体成分和/或身体脂肪的变化 分布将预测冠状动脉危险因素测量的变化 例如甘油三酯、高密度脂蛋白-胆固醇和空腹胰岛素水平。 我们的初步分析显示，基线体脂分布，如 以腰臀比(WHR)衡量，是最好的血清预测指标 老年人甘油三酯水平、高密度脂蛋白-胆固醇和空腹胰岛素水平 与其他一些女性相比，患有冠心病的女性 临床上可用的措施，如膳食中大量营养素的摄入量。 另一方面，峰值有氧能力是预测低密度脂蛋白的最佳指标。 胆固醇。我们很快就会重新分析我们的基线预测数据 包括性别和整个年龄段。此外，我们还将 运动训练对体脂分布的影响及相关因素分析 冠状动脉危险因素。