KINETICS AND MODELING OF THE UREA CYCLE INTERMEDIATE METABOLISM

尿素循环中间代谢的动力学和建模

• 批准号: 6115549
• 负责人: VERNON R YOUNG
• 金额: $ 4.04万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6115549
• 关键词: aminoacid metabolism; arginine; citrulline; clinical research; dietary aminoacid; dietary control; human subject; injection /infusion; model design /development; nutrition related tag; ornithine; pharmacokinetics; urea cycle

To generate data on arginine/citrulline/orthinine metabolsim using a labeled amino acid infusion approach which will provide the information necessary to develop a kinetic model. To use complex labeled amino acids to test the validity of the model previously generated. These data will serve as phase 1 in a complex set of diet studies to be carried out subsequently, beginning with an investigation of an arginine-free diet.

使用标记氨基酸输注方法生成精氨酸/瓜氨酸/邻甲氨蝶呤代谢数据，该方法将提供开发动力学模型所需的信息。 使用复杂的标记氨基酸来测试先前生成的模型的有效性。 这些数据将作为随后进行的一系列复杂饮食研究的第1阶段，首先是对无马槟榔碱饮食的研究。