EFFECT OF SHORT TERM FASTING ON ENERGY METABOLISM--DIFFERENCES BETWEEN SEXES

短期禁食对能量代谢的影响——性别差异

• 批准号: 6305699
• 负责人: VERNON R YOUNG
• 金额: $ 4.04万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2001-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6305699
• 关键词: adipose tissue; bioenergetics; body composition; body weight; calorimetry; clinical research; dietary proteins; fasting; gender difference; glucose metabolism; human subject; lipid metabolism; nutrition related tag; protein metabolism; stable isotope

Indirect calorimetry and stable isotope technique will be used to investigate the progressive (temporal) alterations in lipid, glucose and protein metabolism during short-term fasting in young women and men, who meet the military body-weight and percent body-fat standards. Moreover, we will test the hypothesis that a prior high intake of protein (2.5 g/kg-1/day-1) modifies the metabolic response to a short-term (3 day) fast, with preferential sparing of body protein in both women and men.

间接量热法和稳定同位素技术将用于研究符合军事体重和体脂百分比标准的年轻女性和男性在短期禁食期间脂质、葡萄糖和蛋白质代谢的渐进（时间）变化。此外，我们将测试以下假设：先前摄入大量蛋白质（2.5 g/kg-1/day-1）会改变对短期（3 天）禁食的代谢反应，并且女性和男性都会优先保留体内蛋白质。